Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327891593> ?p ?o ?g. }
- W2327891593 endingPage "4364" @default.
- W2327891593 startingPage "4354" @default.
- W2327891593 abstract "To investigate the functions of the different Raf genes in hematopoietic cell proliferation, the capacities of beta-estradiol-regulated Delta Raf:ER genes to induce cell cycle regulatory gene expression and cell cycle progression in FDC-P1 cells were examined. Raf activation increased the expression of Cdk2, Cdk4, cyclin A, cyclin D, cyclin E, p21(Cip1) and c-Myc and decreased the expression of p27(Kip1) which are associated with G(1) progression. However only the cell clones with moderate Raf activation, i.e. FD/Delta Raf-1:ER and FD/Delta A-Raf:ER, successfully underwent cell proliferation. The cell clones with the highest Delta Raf activity, FD/Delta B-Raf:ER, underwent apoptosis before cell proliferation. p21(Cip1) induced by Raf activation specifically bound with Cdk4/cyclin D complexes but not Cdk2/cyclin E complexes and this binding was associated with the increased Cdk4 activity. However, no binding of p27(Kip1) with either Cdk2/cyclin E or Cdk4/cyclin D was observed. Thus Raf mediated growth was associated with elevated p21(Cip1) expression, which may specifically bind with and activate Cdk4/cyclin D complexes and with decreased p27(Kip1) expression." @default.
- W2327891593 created "2016-06-24" @default.
- W2327891593 creator A5030391285 @default.
- W2327891593 creator A5067645756 @default.
- W2327891593 date "2001-07-19" @default.
- W2327891593 modified "2023-10-18" @default.
- W2327891593 title "P21Cip1 induced by Raf is associated with increased Cdk4 activity in hematopoietic cells" @default.
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