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- W2327923443 abstract "R A L A B ST R A C T S contradictory results for the associations of sodium and potassium intake with CVD incidence, and these associations have not been investigated in patients with CKD. Objectives: To assess the prospective associations between urinary sodium and potassium excretion and CVD incidence among patients with CKD. Methods: The Chronic Renal Insufficiency Cohort Study (CRIC) is a prospective cohort study of 3,939 participants with CKD from seven locations in the United States. Dietary sodium and potassium intake are averaged from three 24-hour urine samples, and the ratios of sodium and potassium to urinary creatinine are used. Composite CVD is defined as incident myocardial infarction (MI), stroke, or congestive heart failure (CHF). CVD events are reported every six months and confirmed by medical record adjudication. Results: Over an average 6.5 years of follow-up, 660 CVD events occurred. The highest quartile (>199.5 mmol/1,374 mg) of the sodium-to-creatinine ratio had a hazard ratio (HR) of 1.58 (95% confidence interval 1.27, 1.97; p for trend across quartiles 69.8 mmol/1,374 mg) of the potassium-to-creatinine ratio had a HR of 1.61 (1.28, 2.03; p for trend across quartiles 0.0002) for composite CVD events compared to the lowest quartile ( 42.3 mmol/ 1,374 mg). When modeled continuously, every 100-mmol higher sodium to 1,374 mg creatinine ratio was associated with an increased HR of 1.23 (1.12, 1.35) for composite CVD events, 1.23 (1.11, 1.37) for CHF, 1.35 (1.11, 1.64) for stroke, and 1.12 (0.96, 1.32) for MI. In addition, every 50-mmol higher potassium to 1,374 mg creatinine ratio was associated with an increased HR of 1.27 (1.11, 1.44) for composite CVD events, 1.35 (1.17, 1.56) for CHF, 1.14 (0.82, 1.59) for stroke, and 1.03 (0.81, 1.32) for MI. Conclusion: Our study found that dietary sodium and potassium are both associatedwith an increased risk of CVD among patients with CKD. These findings suggest that reductions in dietary sodium and potassiummight reduce the incidence of CVD among patients with CKD. Disclosure of Interest: None Declared" @default.
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- W2327923443 date "2014-03-01" @default.
- W2327923443 modified "2023-09-22" @default.
- W2327923443 title "O212 Predictive Value of Lipoprotein Parameters on the Risk of Chronic Kidney Disease in Patients with Coronary Heart Disease" @default.
- W2327923443 doi "https://doi.org/10.1016/j.gheart.2014.03.1417" @default.
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