FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2327946875> ?p ?o ?g. }

• W2327946875 endingPage "835" @default.
• W2327946875 startingPage "835" @default.
• W2327946875 abstract "Tritrichomonas foetus infections were eliminated from six bulls by the oral administration of dimetridazole at the rate of 50 mg/kg body weight daily for 5 consecutive days. The chemical was given either by capsule, or admixed with the feed. Five daily doses at 25 mg/kg administered by capsule freed another bull of T. foetus, but this level was ineffective when fed in grain to two bulls. One of the latter subsequently became negative after repeated courses of treatment at higher dosages. The other bull retained the infection. Bovine venereal trichomoniasis, according to Levine (1961), probably is the third-ranking cause of abortion in cattle. Secondary complications, such as endometritis and pyometra, also contribute to the economic losses occasioned by infections of Tritrichomonas foetus. Levine, in 1961, summarized the extensive literature on this parasite. Subsequent reports pertinent to the chemotherapy of the disease include those of Francis and Collins (1963), Fitzgerald et al. (1963), Gasparini et al. (1963), Rigoulet (1963), and McLoughlin (1963, 1964). The first two papers deal with topical application of therapeutic agents, and the others with the systemic use of imidazole derivatives. Although encompassing much of the material included in brief earlier notes (loc. cit.), this report presents more comprehensive and detailed observations on the oral use of dimetridazole (1,2-dimethyl-5-nitroimidazole) against T. foetus infections in bulls. MATERIALS AND METHODS Experimentally infected bulls were used throughout. The animals were anesthestized, or adequately tranquilized, the penis withdrawn from the sheath, scarified, and then massaged with the trichomonad culture. The animals were examined 1 week after exposure to the parasite and were reexamined prior to treatment to verify the infection. In no instance was an established infection spontaneously lost. Preand posttreatment examinations were made by pipetting physiological saline into the prepuce, closing the opening by hand, and massaging for several minutes. The washings were then collected, centrifuged, and portions of the sediment used to inoculate tubes of Diamond's medium (Diamond, 1957); other portions were examined microscopically for trichomonads. The cultures were examined after intervals of 48, 120, and 144 hr. Received for publication 5 April 1965. The animals were weighed at the last pretreatment examination. Dimetridazole (supplied through the courtesy of Rhodia, Inc., New York, N. Y.) was administered either by capsule with the aid of a balling gun, or admixed in the daily grain ration in dosages of 25 to 100 mg/kg body weight. Each course of treatment lasted 5 days. With the 50-mg dosage administered in the feed, it was necessary to mask the flavor of the medicated grain with molasses after the 2nd day, and finally to withhold all other feed after the 4th day to assure total consumption of the medicament. At least three negative posttreatment examinations during a period of 1 to 7 months were made before an animal was considered free of the disease. Two of the treated bulls were test-bred, and one animal was necropsied." @default.
• W2327946875 created "2016-06-24" @default.
• W2327946875 creator A5020240552 @default.
• W2327946875 date "1965-10-01" @default.
• W2327946875 modified "2023-09-23" @default.
• W2327946875 title "Dimetridazole, a Systemic Treatment for Bovine Venereal Trichomoniasis. I. Oral Administration" @default.
• W2327946875 cites W2047478018 @default.
• W2327946875 cites W2067677555 @default.
• W2327946875 cites W2094936968 @default.
• W2327946875 cites W2320701098 @default.
• W2327946875 cites W2403806916 @default.
• W2327946875 cites W2411725384 @default.
• W2327946875 doi "https://doi.org/10.2307/3276171" @default.
• W2327946875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5857286" @default.
• W2327946875 hasPublicationYear "1965" @default.
• W2327946875 type Work @default.
• W2327946875 sameAs 2327946875 @default.
• W2327946875 citedByCount "7" @default.
• W2327946875 countsByYear W23279468752016 @default.
• W2327946875 countsByYear W23279468752020 @default.
• W2327946875 crossrefType "journal-article" @default.
• W2327946875 hasAuthorship W2327946875A5020240552 @default.
• W2327946875 hasConcept C150903083 @default.
• W2327946875 hasConcept C17744445 @default.
• W2327946875 hasConcept C199539241 @default.
• W2327946875 hasConcept C207001950 @default.
• W2327946875 hasConcept C25938499 @default.
• W2327946875 hasConcept C2777023796 @default.
• W2327946875 hasConcept C2779397712 @default.
• W2327946875 hasConcept C2780765947 @default.
• W2327946875 hasConcept C2781114625 @default.
• W2327946875 hasConcept C29456083 @default.
• W2327946875 hasConcept C71924100 @default.
• W2327946875 hasConcept C86803240 @default.
• W2327946875 hasConcept C89423630 @default.
• W2327946875 hasConceptScore W2327946875C150903083 @default.
• W2327946875 hasConceptScore W2327946875C17744445 @default.
• W2327946875 hasConceptScore W2327946875C199539241 @default.
• W2327946875 hasConceptScore W2327946875C207001950 @default.
• W2327946875 hasConceptScore W2327946875C25938499 @default.
• W2327946875 hasConceptScore W2327946875C2777023796 @default.
• W2327946875 hasConceptScore W2327946875C2779397712 @default.
• W2327946875 hasConceptScore W2327946875C2780765947 @default.
• W2327946875 hasConceptScore W2327946875C2781114625 @default.
• W2327946875 hasConceptScore W2327946875C29456083 @default.
• W2327946875 hasConceptScore W2327946875C71924100 @default.
• W2327946875 hasConceptScore W2327946875C86803240 @default.
• W2327946875 hasConceptScore W2327946875C89423630 @default.
• W2327946875 hasIssue "5" @default.
• W2327946875 hasLocation W23279468751 @default.
• W2327946875 hasLocation W23279468752 @default.
• W2327946875 hasOpenAccess W2327946875 @default.
• W2327946875 hasPrimaryLocation W23279468751 @default.
• W2327946875 hasRelatedWork W1978212860 @default.
• W2327946875 hasRelatedWork W2041413941 @default.
• W2327946875 hasRelatedWork W2055561152 @default.
• W2327946875 hasRelatedWork W2095386171 @default.
• W2327946875 hasRelatedWork W2407716909 @default.
• W2327946875 hasRelatedWork W2414258179 @default.
• W2327946875 hasRelatedWork W2419114714 @default.
• W2327946875 hasRelatedWork W3089492726 @default.
• W2327946875 hasRelatedWork W3091420854 @default.
• W2327946875 hasRelatedWork W3127284038 @default.
• W2327946875 hasVolume "51" @default.
• W2327946875 isParatext "false" @default.
• W2327946875 isRetracted "false" @default.
• W2327946875 magId "2327946875" @default.
• W2327946875 workType "article" @default.