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- W2327990882 abstract "The marine environment is a rich source of metabolites with potential therapeutic properties and applications for humans. Here we describe the first isolation, solid-phase total synthesis, and full structural assignment of a new class of cyclodepsipeptides from the Madagascan sponge Ecionemia acervus that shows in vitro cytotoxic activities at submicromolar concentrations. Seven structures belonging to a new family of compounds, given the general name stellatolides, were characterized. The sequence and stereochemistry of all the amino acids in these molecules were established by a combination of spectroscopic analysis, chemical degradation, and derivatization studies. Furthermore, the complete structure of stellatolide A was confirmed by an efficient solid-phase method for the first total synthesis and the full structural assignment of this molecule, including the asymmetric synthesis of the unique β-hydroxy acid moiety (Z)-3-hydroxy-6,8-dimethylnon-4-enoic acid." @default.
- W2327990882 created "2016-06-24" @default.
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- W2327990882 date "2014-04-29" @default.
- W2327990882 modified "2023-10-09" @default.
- W2327990882 title "Stellatolides, a New Cyclodepsipeptide Family from the Sponge <i>Ecionemia acervus</i>: Isolation, Solid-Phase Total Synthesis, and Full Structural Assignment of Stellatolide A" @default.
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- W2327990882 doi "https://doi.org/10.1021/ja502744a" @default.
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