FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328011012> ?p ?o ?g. }

• W2328011012 endingPage "1859" @default.
• W2328011012 startingPage "1852" @default.
• W2328011012 abstract "Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesics and preventative agents for vascular events. It is unclear whether their long-term use affects cancer risk. Data on the chemopreventative role of these drugs on the risk of the upper aerodigestive tract cancer (UADT) are insufficient and mostly refer to oesophageal cancer. The aim of this study was to investigate the effect of aspirin and other NSAIDs on the risk of UADT cancers. A nested case–control study using the Primary Care Clinical Informatics Unit (PCCIU) database. Conditional logistics regression was used for data analysis. There were 2392 cases of UADT cancer diagnosed between 1996 and 2010 and 7165 age-, gender- and medical practice-matched controls from 131 general medical practices. Mean age of cases was 66 years (s.d. 12) and most were male (63%). Aspirin was prescribed in a quarter of cases and controls, COX-2 inhibitors in 4% of cases and 5% of controls and other NSAIDs in 33% of cases and 36% of controls. Aspirin prescription was associated with a nonsignificant risk reduction of cancer of UADT (adjusted OR=0.9, 95% CI=0.8, 1.0), head and neck (HN; adjusted OR=0.9, 95% CI=0.7, 1.1) or the oesophagus (adjusted OR=0.8, 95% CI=0.7, 1.0). Similar results were found for COX-2 inhibitors prescription. Prescription of other NSAIDs was associated with significantly reduced risk of cancer of UADT (adjusted OR=0.8, 95% CI=0.7, 0.9), HN (adjusted OR=0.8, 95% CI=0.7, 0.9) and the oesophagus (adjusted OR=0.8, 95% CI=0.7, 0.9). An increased volume of aspirin prescriptions was associated with a significant risk reduction (test for trend P<0.001). The decreased risk of cancer of the UADT associated with the use of non-COX-2 inhibitors, NSAIDs and long-term aspirin therapy warrants further exploration of the benefits vs risks of the use of these agents." @default.
• W2328011012 created "2016-06-24" @default.
• W2328011012 creator A5015639182 @default.
• W2328011012 creator A5060182375 @default.
• W2328011012 creator A5075178744 @default.
• W2328011012 date "2014-09-11" @default.
• W2328011012 modified "2023-10-18" @default.
• W2328011012 title "Aspirin and non-steroidal anti-inflammatory drug use and the risk of upper aerodigestive tract cancer" @default.
• W2328011012 cites W1795069710 @default.
• W2328011012 cites W1975875177 @default.
• W2328011012 cites W1977664276 @default.
• W2328011012 cites W1977950682 @default.
• W2328011012 cites W1984452143 @default.
• W2328011012 cites W1990056225 @default.
• W2328011012 cites W1990564784 @default.
• W2328011012 cites W2013187728 @default.
• W2328011012 cites W2020407900 @default.
• W2328011012 cites W2030805781 @default.
• W2328011012 cites W2036193982 @default.
• W2328011012 cites W2039812548 @default.
• W2328011012 cites W2045621412 @default.
• W2328011012 cites W2050829453 @default.
• W2328011012 cites W2068103119 @default.
• W2328011012 cites W2081522627 @default.
• W2328011012 cites W2107283868 @default.
• W2328011012 cites W2111175587 @default.
• W2328011012 cites W2117626104 @default.
• W2328011012 cites W2126945850 @default.
• W2328011012 cites W2136821155 @default.
• W2328011012 cites W2142422008 @default.
• W2328011012 cites W2144939024 @default.
• W2328011012 cites W2151036184 @default.
• W2328011012 cites W2151324279 @default.
• W2328011012 cites W2153082050 @default.
• W2328011012 cites W2158310507 @default.
• W2328011012 cites W2163732932 @default.
• W2328011012 cites W2342166036 @default.
• W2328011012 doi "https://doi.org/10.1038/bjc.2014.473" @default.
• W2328011012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4453731" @default.
• W2328011012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25211662" @default.
• W2328011012 hasPublicationYear "2014" @default.
• W2328011012 type Work @default.
• W2328011012 sameAs 2328011012 @default.
• W2328011012 citedByCount "27" @default.
• W2328011012 countsByYear W23280110122015 @default.
• W2328011012 countsByYear W23280110122016 @default.
• W2328011012 countsByYear W23280110122017 @default.
• W2328011012 countsByYear W23280110122018 @default.
• W2328011012 countsByYear W23280110122019 @default.
• W2328011012 countsByYear W23280110122020 @default.
• W2328011012 countsByYear W23280110122021 @default.
• W2328011012 crossrefType "journal-article" @default.
• W2328011012 hasAuthorship W2328011012A5015639182 @default.
• W2328011012 hasAuthorship W2328011012A5060182375 @default.
• W2328011012 hasAuthorship W2328011012A5075178744 @default.
• W2328011012 hasBestOaLocation W23280110121 @default.
• W2328011012 hasConcept C121608353 @default.
• W2328011012 hasConcept C126322002 @default.
• W2328011012 hasConcept C141071460 @default.
• W2328011012 hasConcept C2426938 @default.
• W2328011012 hasConcept C2776530083 @default.
• W2328011012 hasConcept C2777628954 @default.
• W2328011012 hasConcept C2780035454 @default.
• W2328011012 hasConcept C71924100 @default.
• W2328011012 hasConcept C98274493 @default.
• W2328011012 hasConceptScore W2328011012C121608353 @default.
• W2328011012 hasConceptScore W2328011012C126322002 @default.
• W2328011012 hasConceptScore W2328011012C141071460 @default.
• W2328011012 hasConceptScore W2328011012C2426938 @default.
• W2328011012 hasConceptScore W2328011012C2776530083 @default.
• W2328011012 hasConceptScore W2328011012C2777628954 @default.
• W2328011012 hasConceptScore W2328011012C2780035454 @default.
• W2328011012 hasConceptScore W2328011012C71924100 @default.
• W2328011012 hasConceptScore W2328011012C98274493 @default.
• W2328011012 hasIssue "9" @default.
• W2328011012 hasLocation W23280110121 @default.
• W2328011012 hasLocation W23280110122 @default.
• W2328011012 hasLocation W23280110123 @default.
• W2328011012 hasLocation W23280110124 @default.
• W2328011012 hasLocation W23280110125 @default.
• W2328011012 hasOpenAccess W2328011012 @default.
• W2328011012 hasPrimaryLocation W23280110121 @default.
• W2328011012 hasRelatedWork W124733979 @default.
• W2328011012 hasRelatedWork W1889629264 @default.
• W2328011012 hasRelatedWork W1979895878 @default.
• W2328011012 hasRelatedWork W2072631600 @default.
• W2328011012 hasRelatedWork W2126278804 @default.
• W2328011012 hasRelatedWork W2143014395 @default.
• W2328011012 hasRelatedWork W2151231973 @default.
• W2328011012 hasRelatedWork W2181745077 @default.
• W2328011012 hasRelatedWork W2321381854 @default.
• W2328011012 hasRelatedWork W4382918553 @default.
• W2328011012 hasVolume "111" @default.
• W2328011012 isParatext "false" @default.
• W2328011012 isRetracted "false" @default.
• W2328011012 magId "2328011012" @default.
• W2328011012 workType "article" @default.