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- W2328064113 abstract "HIV infection leads to ongoing immune activation and inflammation within gut-associated lymphoid tissue. Host response initiates events that participate in CD4+ T cell depletion and soft-tissue wasting. Chronic immune activation is associated with disruption of organized lymphoid tissue and gut-barrier integrity, and microbial translocation that may impact whole-body energy metabolism and protein turnover. Systemic stress leading to decreased food intake and/or viral damage to endocrine tissue is associated with wasting disease in HIV-infected patients. Clinical management requires appreciation of subjective, physical, and biochemical parameters, as well as addressing factors associated with food insecurity." @default.
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- W2328064113 date "2011-01-01" @default.
- W2328064113 modified "2023-09-25" @default.
- W2328064113 title "Wasting Disease, Chronic Immune Activation, and Inflammation in the HIV-Infected Patient" @default.
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- W2328064113 doi "https://doi.org/10.1097/tin.0b013e318209e3a0" @default.
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