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- W23281032 abstract "Angiotensin II (Ang II) is the principal mediator of the Renin-Angiotensin System, but other peptides may have a role, including Ang IV and Ang 1–7. Our understanding of Ang II receptor heterogeneity has been facilitated by the discovery of nonpeptide receptor antagonists and the cloning of Ang II receptor subtypes. Losartan-sensitivity defines AT, and PD123319 (and CGP42112)-sensitivity defines AT2 receptor subtypes. AT, receptors predominate in most mammalian tissues and subserve the well-known effects of Ang II. The AT2 receptors are abundant in fetal tissue, nonpregnant myometrium, discrete parts of brain, adrenal cortex and medulla, and kidney. The functional significance of the AT2 receptor is largely unknown, but may involve ion channels, “growth”, and cerebral autoregulation. Tremendous strides have been made in understanding the structure, function, and diversity of Ang II receptors. These studies will continue to be facilitated by the advent of new receptor antagonists. Additional research is needed, however, to clarify the role of the mammalian AT2 site and the role of Ang 1–7 and Ang IV." @default.
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- W23281032 date "1995-01-01" @default.
- W23281032 modified "2023-09-27" @default.
- W23281032 title "Angiotensin Receptor Subtypes and their Pharmacology" @default.
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- W23281032 doi "https://doi.org/10.1007/978-3-0348-7218-8_5" @default.
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