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- W2328130764 abstract "P144 A 28-year-old Brazilian white female blood donor was found to be HTLV-I seropositive. She denied drug addiction, travel outside Minas Gerais, extramarital intercourse and was breast fed for 6 months. The mother's patient was also seropositive and had HAM. One of the 3 patient's sisters was HTLV-I seropositive and asymptomatic. The patient's two children and husband were HTLV-I seronegative. She reported a serious seborrheic dermatitis of longlife duration, which was predominantly in the nasal region as a child and in the scalp in adulthood. The neurological, ophthalmologic and laboratorial exams were normal. Skin biopsy specimens from the affected area revealed lymphohistiocytic infiltrate and had a positive HTLV-I nested polymerase chain reaction (PCR). The biopsy of skin area with normal appearance was hystologically normal and HTLV-I PCR negative. The patient has been treated for many years with topical corticosteroides and antihistamines with variable response. After HTLV-I detection, she started continuous therapy with pentoxifylline, 400 mg bid, while carrying on the former drugs. The response to pentoxifylline was very good. This case was illustrative of how apparently healthy HTLV-I adult carriers may present dermatological disease related to the virus. These lesions deserve attention as they might mean a pre-leukemic state. In addition, as seen in this and other families in our cohort, the spreading of the virus by breast feeding in Brazil may be higher than previously thought." @default.
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- W2328130764 date "1999-04-01" @default.
- W2328130764 modified "2023-09-26" @default.
- W2328130764 title "HTLV-I ASSOCIATED DISEASES AND TRANSMISSION IN A FAMILY SETTING IN BELO HORIZONTE, BRAZIL." @default.
- W2328130764 doi "https://doi.org/10.1097/00042560-199904010-00247" @default.
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