Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328136152> ?p ?o ?g. }
- W2328136152 endingPage "6316" @default.
- W2328136152 startingPage "6307" @default.
- W2328136152 abstract "Understanding the interrelation between surface chemistry of colloidal particles and surface adsorption of biomolecules is a crucial prerequisite for the design of materials for biotechnological and nanomedical applications. Here, we elucidate how tailoring the surface chemistry of colloidal alumina particles (d50 = 180 nm) with amino (−NH2), carboxylate (−COOH), phosphate (−PO3H2) or sulfonate (−SO3H) groups affects adsorption and orientation of the model peptide glutathione disulfide (GSSG). GSSG adsorbed on native, −NH2-functionalized, and −SO3H-functionalized alumina but not on −COOH- and −PO3H2-functionalized particles. When adsorption occurred, the process was rapid (≤5 min), reversible by application of salts, and followed a Langmuir adsorption isotherm dependent on the particle surface functionalization and ζ potential. The orientation of particle bound GSSG was assessed by the release of glutathione after reducing the GSSG disulfide bond and by ζ potential measurements. GSSG is likely to bind via the carboxylate groups of one of its two glutathionyl (GS) moieties onto native and −NH2-modified alumina, whereas GSSG is suggested to bind to −SO3H-modified alumina via the primary amino groups of both GS moieties. Thus, GSSG adsorption and orientation can be tailored by varying the molecular composition of the particle surface, demonstrating a step toward guiding interactions of biomolecules with colloidal particles." @default.
- W2328136152 created "2016-06-24" @default.
- W2328136152 creator A5014772212 @default.
- W2328136152 creator A5029055108 @default.
- W2328136152 creator A5043372210 @default.
- W2328136152 creator A5049959862 @default.
- W2328136152 creator A5062425172 @default.
- W2328136152 creator A5077770397 @default.
- W2328136152 creator A5080178391 @default.
- W2328136152 date "2013-04-16" @default.
- W2328136152 modified "2023-10-03" @default.
- W2328136152 title "Adsorption and Orientation of the Physiological Extracellular Peptide Glutathione Disulfide on Surface Functionalized Colloidal Alumina Particles" @default.
- W2328136152 cites W1509452365 @default.
- W2328136152 cites W1546531301 @default.
- W2328136152 cites W1558564171 @default.
- W2328136152 cites W1966090623 @default.
- W2328136152 cites W1966808630 @default.
- W2328136152 cites W1967695098 @default.
- W2328136152 cites W1974010403 @default.
- W2328136152 cites W1975508977 @default.
- W2328136152 cites W1976798209 @default.
- W2328136152 cites W1988762263 @default.
- W2328136152 cites W1989734247 @default.
- W2328136152 cites W1994295660 @default.
- W2328136152 cites W2004215840 @default.
- W2328136152 cites W2007064404 @default.
- W2328136152 cites W2018588008 @default.
- W2328136152 cites W2019347292 @default.
- W2328136152 cites W2020497680 @default.
- W2328136152 cites W2021270810 @default.
- W2328136152 cites W2025501525 @default.
- W2328136152 cites W2026516230 @default.
- W2328136152 cites W2029582401 @default.
- W2328136152 cites W2029667189 @default.
- W2328136152 cites W2035938050 @default.
- W2328136152 cites W2037772024 @default.
- W2328136152 cites W2038347578 @default.
- W2328136152 cites W2040601222 @default.
- W2328136152 cites W2042060162 @default.
- W2328136152 cites W2044493548 @default.
- W2328136152 cites W2049502419 @default.
- W2328136152 cites W2050884068 @default.
- W2328136152 cites W2062669701 @default.
- W2328136152 cites W2067769271 @default.
- W2328136152 cites W2074881820 @default.
- W2328136152 cites W2076996612 @default.
- W2328136152 cites W2089669286 @default.
- W2328136152 cites W2091417967 @default.
- W2328136152 cites W2110634891 @default.
- W2328136152 cites W2114559046 @default.
- W2328136152 cites W2116999937 @default.
- W2328136152 cites W2122330015 @default.
- W2328136152 cites W2141828887 @default.
- W2328136152 cites W2154265087 @default.
- W2328136152 cites W2158558808 @default.
- W2328136152 cites W2160864796 @default.
- W2328136152 cites W2316306457 @default.
- W2328136152 cites W2326294098 @default.
- W2328136152 cites W2328147470 @default.
- W2328136152 cites W2478510834 @default.
- W2328136152 cites W4233418655 @default.
- W2328136152 doi "https://doi.org/10.1021/ja401590c" @default.
- W2328136152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23565729" @default.
- W2328136152 hasPublicationYear "2013" @default.
- W2328136152 type Work @default.
- W2328136152 sameAs 2328136152 @default.
- W2328136152 citedByCount "28" @default.
- W2328136152 countsByYear W23281361522013 @default.
- W2328136152 countsByYear W23281361522014 @default.
- W2328136152 countsByYear W23281361522015 @default.
- W2328136152 countsByYear W23281361522016 @default.
- W2328136152 countsByYear W23281361522017 @default.
- W2328136152 countsByYear W23281361522018 @default.
- W2328136152 countsByYear W23281361522019 @default.
- W2328136152 countsByYear W23281361522020 @default.
- W2328136152 countsByYear W23281361522021 @default.
- W2328136152 countsByYear W23281361522022 @default.
- W2328136152 countsByYear W23281361522023 @default.
- W2328136152 crossrefType "journal-article" @default.
- W2328136152 hasAuthorship W2328136152A5014772212 @default.
- W2328136152 hasAuthorship W2328136152A5029055108 @default.
- W2328136152 hasAuthorship W2328136152A5043372210 @default.
- W2328136152 hasAuthorship W2328136152A5049959862 @default.
- W2328136152 hasAuthorship W2328136152A5062425172 @default.
- W2328136152 hasAuthorship W2328136152A5077770397 @default.
- W2328136152 hasAuthorship W2328136152A5080178391 @default.
- W2328136152 hasConcept C111368507 @default.
- W2328136152 hasConcept C115537861 @default.
- W2328136152 hasConcept C127313418 @default.
- W2328136152 hasConcept C127413603 @default.
- W2328136152 hasConcept C147789679 @default.
- W2328136152 hasConcept C150394285 @default.
- W2328136152 hasConcept C178790620 @default.
- W2328136152 hasConcept C179104552 @default.
- W2328136152 hasConcept C181199279 @default.
- W2328136152 hasConcept C185592680 @default.
- W2328136152 hasConcept C21951064 @default.
- W2328136152 hasConcept C2778074193 @default.