FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328162493> ?p ?o ?g. }

• W2328162493 endingPage "e151" @default.
• W2328162493 startingPage "e144" @default.
• W2328162493 abstract "Background: Information on antiretroviral therapy (ART) use in HIV-infected children with severe malnutrition (SM) is lacking. We investigated long-term ART outcomes in this population. Methods: Children enrolled in the TREAT Asia Pediatric HIV Observational Database who had SM (weight-for-height or body mass index–for-age Z score less than −3) at ART initiation were analyzed. Generalized estimating equations were used to investigate poor weight recovery (weight-for-age Z score less than −3) and poor CD4% recovery (CD4% <25), and competing risk regression was used to analyze mortality and toxicity-associated treatment modification. Results: Three hundred fifty-five (11.9%) of 2993 children starting ART had SM. Their median weight-for-age Z score increased from −5.6 at ART initiation to −2.3 after 36 months. Not using trimethoprim–sulfamethoxazole prophylaxis at baseline was associated with poor weight recovery [odds ratio: 2.49 vs. using; 95% confidence interval (CI): 1.66–3.74; P < 0.001]. Median CD4% increased from 3.0 at ART initiation to 27.2 after 36 months, and 56 (15.3%) children died during follow-up. More profound SM was associated with poor CD4% recovery (odds ratio: 1.78 for Z score less than −4.5 vs. −3.5 to less than −3.0; 95% CI: 1.08–2.92; P = 0.023) and mortality (hazard ratio: 2.57 for Z score less than −4.5 vs. −3.5 to less than −3.0; 95% CI: 1.24–5.33; P = 0.011). Twenty-two toxicity-associated ART modifications occurred at a rate of 2.4 per 100 patient-years, and rates did not differ by malnutrition severity. Conclusion: Trimethoprim–sulfamethoxazole prophylaxis is important for the recovery of weight-for-age in severely malnourished children starting ART. The extent of SM does not impede weight-for-age recovery or antiretroviral tolerability, but CD4% response is compromised in children with a very low weight-for-height/body mass index-for-age Z score, which may contribute to their high rate of mortality." @default.
• W2328162493 created "2016-06-24" @default.
• W2328162493 creator A5006666582 @default.
• W2328162493 creator A5008178574 @default.
• W2328162493 creator A5009499406 @default.
• W2328162493 creator A5014680337 @default.
• W2328162493 creator A5015042177 @default.
• W2328162493 creator A5029006123 @default.
• W2328162493 creator A5031593281 @default.
• W2328162493 creator A5038605024 @default.
• W2328162493 creator A5042491405 @default.
• W2328162493 creator A5050114438 @default.
• W2328162493 creator A5051259565 @default.
• W2328162493 creator A5056462251 @default.
• W2328162493 creator A5067152787 @default.
• W2328162493 creator A5069381510 @default.
• W2328162493 creator A5073643745 @default.
• W2328162493 creator A5081328251 @default.
• W2328162493 creator A5087295454 @default.
• W2328162493 date "2016-05-01" @default.
• W2328162493 modified "2023-09-27" @default.
• W2328162493 title "Antiretroviral Therapy in Severely Malnourished, HIV-infected Children in Asia" @default.
• W2328162493 cites W1516480248 @default.
• W2328162493 cites W1650437557 @default.
• W2328162493 cites W1653524466 @default.
• W2328162493 cites W1965033387 @default.
• W2328162493 cites W1968988227 @default.
• W2328162493 cites W1970709140 @default.
• W2328162493 cites W1977480201 @default.
• W2328162493 cites W1982760425 @default.
• W2328162493 cites W1987018399 @default.
• W2328162493 cites W1991706608 @default.
• W2328162493 cites W2000795003 @default.
• W2328162493 cites W2009940629 @default.
• W2328162493 cites W2023895786 @default.
• W2328162493 cites W2043899477 @default.
• W2328162493 cites W2053450998 @default.
• W2328162493 cites W2097345834 @default.
• W2328162493 cites W2110278919 @default.
• W2328162493 cites W2111932307 @default.
• W2328162493 cites W2119309685 @default.
• W2328162493 cites W2121743761 @default.
• W2328162493 cites W2137247340 @default.
• W2328162493 cites W2142474096 @default.
• W2328162493 cites W2168039974 @default.
• W2328162493 cites W2186508522 @default.
• W2328162493 doi "https://doi.org/10.1097/inf.0000000000001074" @default.
• W2328162493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4829479" @default.
• W2328162493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26835972" @default.
• W2328162493 hasPublicationYear "2016" @default.
• W2328162493 type Work @default.
• W2328162493 sameAs 2328162493 @default.
• W2328162493 citedByCount "11" @default.
• W2328162493 countsByYear W23281624932016 @default.
• W2328162493 countsByYear W23281624932018 @default.
• W2328162493 countsByYear W23281624932019 @default.
• W2328162493 countsByYear W23281624932020 @default.
• W2328162493 countsByYear W23281624932022 @default.
• W2328162493 countsByYear W23281624932023 @default.
• W2328162493 crossrefType "journal-article" @default.
• W2328162493 hasAuthorship W2328162493A5006666582 @default.
• W2328162493 hasAuthorship W2328162493A5008178574 @default.
• W2328162493 hasAuthorship W2328162493A5009499406 @default.
• W2328162493 hasAuthorship W2328162493A5014680337 @default.
• W2328162493 hasAuthorship W2328162493A5015042177 @default.
• W2328162493 hasAuthorship W2328162493A5029006123 @default.
• W2328162493 hasAuthorship W2328162493A5031593281 @default.
• W2328162493 hasAuthorship W2328162493A5038605024 @default.
• W2328162493 hasAuthorship W2328162493A5042491405 @default.
• W2328162493 hasAuthorship W2328162493A5050114438 @default.
• W2328162493 hasAuthorship W2328162493A5051259565 @default.
• W2328162493 hasAuthorship W2328162493A5056462251 @default.
• W2328162493 hasAuthorship W2328162493A5067152787 @default.
• W2328162493 hasAuthorship W2328162493A5069381510 @default.
• W2328162493 hasAuthorship W2328162493A5073643745 @default.
• W2328162493 hasAuthorship W2328162493A5081328251 @default.
• W2328162493 hasAuthorship W2328162493A5087295454 @default.
• W2328162493 hasBestOaLocation W23281624932 @default.
• W2328162493 hasConcept C126322002 @default.
• W2328162493 hasConcept C142462285 @default.
• W2328162493 hasConcept C156957248 @default.
• W2328162493 hasConcept C187212893 @default.
• W2328162493 hasConcept C203014093 @default.
• W2328162493 hasConcept C207103383 @default.
• W2328162493 hasConcept C2780221984 @default.
• W2328162493 hasConcept C2780728791 @default.
• W2328162493 hasConcept C2908647359 @default.
• W2328162493 hasConcept C2993143319 @default.
• W2328162493 hasConcept C3013748606 @default.
• W2328162493 hasConcept C44249647 @default.
• W2328162493 hasConcept C501593827 @default.
• W2328162493 hasConcept C71924100 @default.
• W2328162493 hasConcept C86803240 @default.
• W2328162493 hasConcept C89423630 @default.
• W2328162493 hasConcept C99454951 @default.
• W2328162493 hasConceptScore W2328162493C126322002 @default.
• W2328162493 hasConceptScore W2328162493C142462285 @default.
• W2328162493 hasConceptScore W2328162493C156957248 @default.

• next