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- W2328211192 abstract "Multiple prognostic markers are combined to risk-stratify neuroblastoma patients for treatment protocols. One such marker is a histologic assessment using the International Neuroblastoma Pathology Committee classification, which divides patients into favourable and unfavourable categories assessing, together with other parameters, the mitosis-karyorrhexis index (MKI). The recommended counting of 5000 cells to assign MKI is, however, time-consuming and observer-dependent, and there is a potential for inaccuracy. In the present study, we investigated automating an assessment of the MKI using image analysis and MIB-1 (Ki-67) as a surrogate marker. Twenty five cases of neuroblastoma, ranging from low to high MKI, were immunostained for MIB-1. A total of 375 microscopic fields were captured with 109,763 cells scored. The MIB-1 index was determined by image analysis software whereas MKI was obtained by manual counting of the same immunostained fields. There was a significant correlation between the MIB-1 index and the MKI comparing all fields (r = 0.7869, p value" @default.
- W2328211192 created "2016-06-24" @default.
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- W2328211192 date "2014-01-01" @default.
- W2328211192 modified "2023-09-28" @default.
- W2328211192 title "MIB1 index as a surrogate for mitosis-karyorrhexis index in neuroblastoma" @default.
- W2328211192 doi "https://doi.org/10.1097/01.pat.0000454505.03427.09" @default.
- W2328211192 hasPublicationYear "2014" @default.
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