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• W2328227719 endingPage "2417" @default.
• W2328227719 startingPage "2413" @default.
• W2328227719 abstract "As our continuing research on antifungal dihydroisoquinolin-2-ium salts, forty 2-aryl-8-OR-3,4-dihydroisoquinolin-2-ium bromides were synthesized and characterized by spectroscopic analysis. By using the mycelium growth rate method, the compounds were evaluated for antifungal activity against three plant pathogenic fungi and structure–activity relationships (SAR) were derived. The vast majority of the compounds displayed the medium to high activity with inhibition rates of 50–100% at 150 μM. About half of the compounds were more active than their natural model compounds sanguinarine and chelerythrine for all the fungi, and part or most of them were more active than positive drugs thiabendazole and azoxystrobin. SAR analysis showed that both substitution patterns of the C-ring and the type of 8-OR group significantly influenced the activity. Thus, a series of new title compounds with excellent antifungal potency emerged." @default.
• W2328227719 created "2016-06-24" @default.
• W2328227719 creator A5001817156 @default.
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• W2328227719 date "2016-05-01" @default.
• W2328227719 modified "2023-10-17" @default.
• W2328227719 title "Synthesis, bioactivity and structure–activity relationships of new 2-aryl-8-OR-3,4-dihydroisoquinolin-2-iums salts as potential antifungal agents" @default.
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• W2328227719 doi "https://doi.org/10.1016/j.bmcl.2016.04.001" @default.
• W2328227719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27072907" @default.
• W2328227719 hasPublicationYear "2016" @default.
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