FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328241777> ?p ?o ?g. }

• W2328241777 endingPage "1115" @default.
• W2328241777 startingPage "1110" @default.
• W2328241777 abstract "The idea that serotonergic synaptic transmission plays an essential role in the control of mood and the pharmacotherapy of anxiety and depression is one of the cornerstones of modern biological psychiatry. As a result, there is intense interest in understanding the mechanisms controlling the activity of serotonin-synthesizing (serotonergic) neurons. One of the oldest and most durable ideas emerging from this work is that serotonergic neurons are capable of autonomously regulating their own basal firing rate. Serotonergic neurons express on their surface 5-HT1A receptors (autoreceptors) that, when activated, induce the opening of potassium channels that hyperpolarize and thereby inhibit cell firing. Activity-dependent release of serotonin within serotonergic nuclei is thought to activate these autoreceptors, thus completing an autoinhibitory feedback loop. This concept, which was originally proposed in the 1970s, has proven to be enormously fruitful and has guided the interpretation of a broad range of clinical and preclinical work. Yet, remarkably, electrophysiological studies seeking to directly demonstrate this phenomenon, especially in in vitro brain slices, have produced mixed results. Here, we critically review this work with a focus on electrophysiological studies, which directly assess neuronal activity. We also highlight recent work suggesting that 5-HT1A receptor-mediated autoinhibition may play other roles in the control of firing besides acting as a feedback regulator for the pacemaker-like firing rate of serotonergic neurons." @default.
• W2328241777 created "2016-06-24" @default.
• W2328241777 creator A5032595661 @default.
• W2328241777 creator A5042085390 @default.
• W2328241777 creator A5074548471 @default.
• W2328241777 creator A5076432653 @default.
• W2328241777 creator A5076993091 @default.
• W2328241777 date "2015-05-26" @default.
• W2328241777 modified "2023-10-15" @default.
• W2328241777 title "5-HT_1A Receptor-Mediated Autoinhibition and the Control of Serotonergic Cell Firing" @default.
• W2328241777 cites W1238819995 @default.
• W2328241777 cites W1566149803 @default.
• W2328241777 cites W1591523569 @default.
• W2328241777 cites W1828538530 @default.
• W2328241777 cites W1929691281 @default.
• W2328241777 cites W1963690073 @default.
• W2328241777 cites W1970381031 @default.
• W2328241777 cites W1970812735 @default.
• W2328241777 cites W1972160704 @default.
• W2328241777 cites W1973082508 @default.
• W2328241777 cites W1976636888 @default.
• W2328241777 cites W1982102807 @default.
• W2328241777 cites W1982450472 @default.
• W2328241777 cites W1984642996 @default.
• W2328241777 cites W1986160236 @default.
• W2328241777 cites W1988606802 @default.
• W2328241777 cites W1989485566 @default.
• W2328241777 cites W1989900998 @default.
• W2328241777 cites W1992734614 @default.
• W2328241777 cites W2003329156 @default.
• W2328241777 cites W2005453809 @default.
• W2328241777 cites W2007061409 @default.
• W2328241777 cites W2007696006 @default.
• W2328241777 cites W2013576660 @default.
• W2328241777 cites W2019641431 @default.
• W2328241777 cites W2024229086 @default.
• W2328241777 cites W2027671925 @default.
• W2328241777 cites W2028978537 @default.
• W2328241777 cites W2029664342 @default.
• W2328241777 cites W2030848542 @default.
• W2328241777 cites W2039986733 @default.
• W2328241777 cites W2041052894 @default.
• W2328241777 cites W2057971000 @default.
• W2328241777 cites W2058092335 @default.
• W2328241777 cites W2059482977 @default.
• W2328241777 cites W2061261367 @default.
• W2328241777 cites W2061502491 @default.
• W2328241777 cites W2062177692 @default.
• W2328241777 cites W2065133796 @default.
• W2328241777 cites W2068401230 @default.
• W2328241777 cites W2076285845 @default.
• W2328241777 cites W2081784716 @default.
• W2328241777 cites W2103517742 @default.
• W2328241777 cites W2104890744 @default.
• W2328241777 cites W2127567317 @default.
• W2328241777 cites W2146670556 @default.
• W2328241777 cites W2149687002 @default.
• W2328241777 cites W2154706699 @default.
• W2328241777 cites W2158770881 @default.
• W2328241777 cites W2159612818 @default.
• W2328241777 cites W2162598202 @default.
• W2328241777 cites W2167243746 @default.
• W2328241777 cites W2305234959 @default.
• W2328241777 cites W2465223159 @default.
• W2328241777 doi "https://doi.org/10.1021/acschemneuro.5b00034" @default.
• W2328241777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4849862" @default.
• W2328241777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25913021" @default.
• W2328241777 hasPublicationYear "2015" @default.
• W2328241777 type Work @default.
• W2328241777 sameAs 2328241777 @default.
• W2328241777 citedByCount "40" @default.
• W2328241777 countsByYear W23282417772015 @default.
• W2328241777 countsByYear W23282417772016 @default.
• W2328241777 countsByYear W23282417772017 @default.
• W2328241777 countsByYear W23282417772018 @default.
• W2328241777 countsByYear W23282417772019 @default.
• W2328241777 countsByYear W23282417772020 @default.
• W2328241777 countsByYear W23282417772021 @default.
• W2328241777 countsByYear W23282417772022 @default.
• W2328241777 countsByYear W23282417772023 @default.
• W2328241777 crossrefType "journal-article" @default.
• W2328241777 hasAuthorship W2328241777A5032595661 @default.
• W2328241777 hasAuthorship W2328241777A5042085390 @default.
• W2328241777 hasAuthorship W2328241777A5074548471 @default.
• W2328241777 hasAuthorship W2328241777A5076432653 @default.
• W2328241777 hasAuthorship W2328241777A5076993091 @default.
• W2328241777 hasBestOaLocation W23282417772 @default.
• W2328241777 hasConcept C15744967 @default.
• W2328241777 hasConcept C169760540 @default.
• W2328241777 hasConcept C170493617 @default.
• W2328241777 hasConcept C185263204 @default.
• W2328241777 hasConcept C200170125 @default.
• W2328241777 hasConcept C2775864247 @default.
• W2328241777 hasConcept C37000724 @default.
• W2328241777 hasConcept C53910766 @default.
• W2328241777 hasConcept C55493867 @default.
• W2328241777 hasConcept C8439214 @default.
• W2328241777 hasConcept C86803240 @default.

• next