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- W2328247912 abstract "To evaluate the utility of (99m)Tc-fanolesomab (a (99m)Tc-labeled murine monoclonal immunoglobulin M antibody that specifically binds cluster designation 15 antigens on human neutrophillic leukocytes with high sensitivity and specificity) in diagnosing localized infections.Five patients with renal allografts were imaged using (99m)Tc-fanolesomab to look for a source of infection. Images were obtained between 2 and 4 h after injection of fanolesomab labeled with 15-20 mCi (99m)Tc. Imaging results were correlated with patients' culture results and clinical outcome.Two patients showed a significant increase in renal allograft uptake and were found to have allograft pyelonephritis. One patient who developed a severe acute renal failure secondary to humoral rejection (antidonor human leukocyte antigen antibody-mediated rejection with polymorphonuclear capillaritis and glomerulitis) showed uptake similar to the lower lumbar spine. One patient with normal allograft function showed a significantly increased uptake, especially in the pelvis of the allograft, indicating normal excretion of the free (99m)Tc-pertechnetate by the allograft. The fifth patient who had been off immunosuppressive therapy and on maintenance hemodialysis for 4 months showed tracer uptake similar to the lumbar spine, suggestive of chronic allograft rejection.This preliminary study describes different patterns of (99m)Tc-fanolesomab scan in renal allografts during episodes of kidney infection, rejection, or normal function. It suggests that (99m)Tc-fanolesomab can be used to evaluate renal allograft complications." @default.
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- W2328247912 date "2011-10-01" @default.
- W2328247912 modified "2023-09-27" @default.
- W2328247912 title "A preliminary report on 99mTc-fanolesomab imaging of renal allograft" @default.
- W2328247912 doi "https://doi.org/10.1097/mnm.0b013e328348c0fb" @default.
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