FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328333669> ?p ?o ?g. }

• W2328333669 endingPage "208" @default.
• W2328333669 startingPage "201" @default.
• W2328333669 abstract "Electroporation is a physical event that temporarily reduces cell membrane barrier properties. Diminished membrane barrier properties are achieved by exposing cells to pulsed electric fields. When a cell has been treated with electric fields it is possible for extracellular agents to gain access to the cell interior. This process has been used in vivo to increase the uptake of chemotherapeutic agents by tumor cells which results in dramatically higher response rates than when drug is used alone. This type of treatment is called electrochemotherapy (ECT); bleomycin is most often used as the drug for this type of treatment. It was hypothesized that electroporation could be used to augment the cytotoxicity of other anticancer agents. Therefore, this study was performed in order to screen 44 different combinations of drug and cell type in vitro to identify drugs that may have higher cytotoxicity when combined with electroporation. Results from seven cell types indicate that the IC50 of bleomycin can be reduced by a factor of 100-5000 when electroporation is used to facilitate internalization. The IC50 values of cisplatin and carboplatin could be reduced by factors ranging from 3 to 13 in six different cell lines as a result of electroporation. These IC50 reductions in multiple cell lines suggest that cisplatin and carboplatin may be effective in vivo as part of ECT treatment." @default.
• W2328333669 created "2016-06-24" @default.
• W2328333669 creator A5012432635 @default.
• W2328333669 creator A5018434745 @default.
• W2328333669 creator A5021553715 @default.
• W2328333669 creator A5039704798 @default.
• W2328333669 creator A5057362562 @default.
• W2328333669 creator A5060093851 @default.
• W2328333669 date "2000-03-01" @default.
• W2328333669 modified "2023-10-14" @default.
• W2328333669 title "Toxicity of anticancer agents mediated by electroporation in vitro" @default.
• W2328333669 cites W1490324405 @default.
• W2328333669 cites W1521859708 @default.
• W2328333669 cites W1963551591 @default.
• W2328333669 cites W1968285225 @default.
• W2328333669 cites W1972677384 @default.
• W2328333669 cites W1976339696 @default.
• W2328333669 cites W1978542226 @default.
• W2328333669 cites W1979534176 @default.
• W2328333669 cites W1979908488 @default.
• W2328333669 cites W1981268527 @default.
• W2328333669 cites W1989463054 @default.
• W2328333669 cites W1995693057 @default.
• W2328333669 cites W1997458695 @default.
• W2328333669 cites W1998670685 @default.
• W2328333669 cites W2019499382 @default.
• W2328333669 cites W2020236148 @default.
• W2328333669 cites W2052864248 @default.
• W2328333669 cites W2054457322 @default.
• W2328333669 cites W2067861173 @default.
• W2328333669 cites W2139135478 @default.
• W2328333669 cites W2146362841 @default.
• W2328333669 cites W2159703660 @default.
• W2328333669 cites W2159995158 @default.
• W2328333669 doi "https://doi.org/10.1097/00001813-200003000-00008" @default.
• W2328333669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10831279" @default.
• W2328333669 hasPublicationYear "2000" @default.
• W2328333669 type Work @default.
• W2328333669 sameAs 2328333669 @default.
• W2328333669 citedByCount "144" @default.
• W2328333669 countsByYear W23283336692012 @default.
• W2328333669 countsByYear W23283336692013 @default.
• W2328333669 countsByYear W23283336692014 @default.
• W2328333669 countsByYear W23283336692015 @default.
• W2328333669 countsByYear W23283336692016 @default.
• W2328333669 countsByYear W23283336692017 @default.
• W2328333669 countsByYear W23283336692018 @default.
• W2328333669 countsByYear W23283336692019 @default.
• W2328333669 countsByYear W23283336692020 @default.
• W2328333669 countsByYear W23283336692021 @default.
• W2328333669 countsByYear W23283336692022 @default.
• W2328333669 countsByYear W23283336692023 @default.
• W2328333669 crossrefType "journal-article" @default.
• W2328333669 hasAuthorship W2328333669A5012432635 @default.
• W2328333669 hasAuthorship W2328333669A5018434745 @default.
• W2328333669 hasAuthorship W2328333669A5021553715 @default.
• W2328333669 hasAuthorship W2328333669A5039704798 @default.
• W2328333669 hasAuthorship W2328333669A5057362562 @default.
• W2328333669 hasAuthorship W2328333669A5060093851 @default.
• W2328333669 hasConcept C104317684 @default.
• W2328333669 hasConcept C109316439 @default.
• W2328333669 hasConcept C126322002 @default.
• W2328333669 hasConcept C139770010 @default.
• W2328333669 hasConcept C1491633281 @default.
• W2328333669 hasConcept C150903083 @default.
• W2328333669 hasConcept C185592680 @default.
• W2328333669 hasConcept C186852380 @default.
• W2328333669 hasConcept C202751555 @default.
• W2328333669 hasConcept C207001950 @default.
• W2328333669 hasConcept C2776232574 @default.
• W2328333669 hasConcept C2776694085 @default.
• W2328333669 hasConcept C2777108052 @default.
• W2328333669 hasConcept C2778239845 @default.
• W2328333669 hasConcept C2781451048 @default.
• W2328333669 hasConcept C54355233 @default.
• W2328333669 hasConcept C55493867 @default.
• W2328333669 hasConcept C71924100 @default.
• W2328333669 hasConcept C81885089 @default.
• W2328333669 hasConcept C86803240 @default.
• W2328333669 hasConcept C95444343 @default.
• W2328333669 hasConcept C98274493 @default.
• W2328333669 hasConceptScore W2328333669C104317684 @default.
• W2328333669 hasConceptScore W2328333669C109316439 @default.
• W2328333669 hasConceptScore W2328333669C126322002 @default.
• W2328333669 hasConceptScore W2328333669C139770010 @default.
• W2328333669 hasConceptScore W2328333669C1491633281 @default.
• W2328333669 hasConceptScore W2328333669C150903083 @default.
• W2328333669 hasConceptScore W2328333669C185592680 @default.
• W2328333669 hasConceptScore W2328333669C186852380 @default.
• W2328333669 hasConceptScore W2328333669C202751555 @default.
• W2328333669 hasConceptScore W2328333669C207001950 @default.
• W2328333669 hasConceptScore W2328333669C2776232574 @default.
• W2328333669 hasConceptScore W2328333669C2776694085 @default.
• W2328333669 hasConceptScore W2328333669C2777108052 @default.
• W2328333669 hasConceptScore W2328333669C2778239845 @default.
• W2328333669 hasConceptScore W2328333669C2781451048 @default.
• W2328333669 hasConceptScore W2328333669C54355233 @default.
• W2328333669 hasConceptScore W2328333669C55493867 @default.

• next