Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328336468> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2328336468 abstract "The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and bladder carcinogenesis and a potential use of anti-aging agents in bladder cancer chemoprevention. Rhodiola rosea, growing in high altitude or cold regions of the world, has been reported to have anti-aging effects in Drosophila. Metformin, a popular anti-diabetics drug, has also shown anti-aging effect in mice. In addition, both agents have been shown to inhibit the mTOR pathway. Therefore, we examined the effect of SHR-5 and Metformin on bladder carcinogenesis in the UPII-mutant Ha-ras transgenic mouse bladder model. This model mimics human papillary transitional cell carcinoma and exhibits enhanced mTOR activity in the bladder tumors. The homozygous mutant Ha-ras transgenic mice were identified through genotyping using Southern blotting analysis. 0.625% SHR-5 or 0.1% Metformin in drinking water was given to the mice starting at 6 weeks of age and ending at 6 months of age. About 42% of homozygous mutant Ha-ras male transgenic mice which drank normal water died of urinary tract obstruction and hydronephrosis within 6 months of age, while more than 93% and 89% of mice which drank SHR-5 or Metformin containing water survived. The mean bladder weights in male mice drinking SHR-5 or Metformin decreased by 69% and 62%, respectively, compared to control group (Bladder weights for mice drinking normal water versus SHR-5 or Metformin are 0.3382± 0.061versus 0.1278± 0.02 or 0.1053±0.015 gram, P=0.0197 or 0.0082). The mean bladder weights in female mice which drank SHR-5 or Metformin containing water also decreased by about 40% or 39.8 %, respectively, compared to those which drank normal water (Bladder weights for normal water versus SHR-5 or Metformin: 0.07149 ±0.0036 versus 0.04301 ±0.0032 or 0.04295±0.0115 gram, P" @default.
- W2328336468 created "2016-06-24" @default.
- W2328336468 creator A5020189532 @default.
- W2328336468 creator A5036496290 @default.
- W2328336468 creator A5039094381 @default.
- W2328336468 creator A5064775495 @default.
- W2328336468 creator A5082785833 @default.
- W2328336468 creator A5086187744 @default.
- W2328336468 creator A5090805206 @default.
- W2328336468 date "2012-04-15" @default.
- W2328336468 modified "2023-09-27" @default.
- W2328336468 title "Abstract 618:Rhodiola rosea L. extract, SHR-5, and metformin exhibit potent activity against bladder carcinogenesis in the UPII-mutant Ha-ras transgenic model." @default.
- W2328336468 doi "https://doi.org/10.1158/1538-7445.am2012-618" @default.
- W2328336468 hasPublicationYear "2012" @default.
- W2328336468 type Work @default.
- W2328336468 sameAs 2328336468 @default.
- W2328336468 citedByCount "2" @default.
- W2328336468 countsByYear W23283364682015 @default.
- W2328336468 countsByYear W23283364682017 @default.
- W2328336468 crossrefType "proceedings-article" @default.
- W2328336468 hasAuthorship W2328336468A5020189532 @default.
- W2328336468 hasAuthorship W2328336468A5036496290 @default.
- W2328336468 hasAuthorship W2328336468A5039094381 @default.
- W2328336468 hasAuthorship W2328336468A5064775495 @default.
- W2328336468 hasAuthorship W2328336468A5082785833 @default.
- W2328336468 hasAuthorship W2328336468A5086187744 @default.
- W2328336468 hasAuthorship W2328336468A5090805206 @default.
- W2328336468 hasConcept C102230213 @default.
- W2328336468 hasConcept C104317684 @default.
- W2328336468 hasConcept C121608353 @default.
- W2328336468 hasConcept C126322002 @default.
- W2328336468 hasConcept C126894567 @default.
- W2328336468 hasConcept C134018914 @default.
- W2328336468 hasConcept C141035611 @default.
- W2328336468 hasConcept C2777540882 @default.
- W2328336468 hasConcept C2779762690 @default.
- W2328336468 hasConcept C2780323712 @default.
- W2328336468 hasConcept C2780352672 @default.
- W2328336468 hasConcept C55493867 @default.
- W2328336468 hasConcept C555283112 @default.
- W2328336468 hasConcept C555293320 @default.
- W2328336468 hasConcept C71924100 @default.
- W2328336468 hasConcept C77411442 @default.
- W2328336468 hasConcept C86803240 @default.
- W2328336468 hasConcept C98274493 @default.
- W2328336468 hasConceptScore W2328336468C102230213 @default.
- W2328336468 hasConceptScore W2328336468C104317684 @default.
- W2328336468 hasConceptScore W2328336468C121608353 @default.
- W2328336468 hasConceptScore W2328336468C126322002 @default.
- W2328336468 hasConceptScore W2328336468C126894567 @default.
- W2328336468 hasConceptScore W2328336468C134018914 @default.
- W2328336468 hasConceptScore W2328336468C141035611 @default.
- W2328336468 hasConceptScore W2328336468C2777540882 @default.
- W2328336468 hasConceptScore W2328336468C2779762690 @default.
- W2328336468 hasConceptScore W2328336468C2780323712 @default.
- W2328336468 hasConceptScore W2328336468C2780352672 @default.
- W2328336468 hasConceptScore W2328336468C55493867 @default.
- W2328336468 hasConceptScore W2328336468C555283112 @default.
- W2328336468 hasConceptScore W2328336468C555293320 @default.
- W2328336468 hasConceptScore W2328336468C71924100 @default.
- W2328336468 hasConceptScore W2328336468C77411442 @default.
- W2328336468 hasConceptScore W2328336468C86803240 @default.
- W2328336468 hasConceptScore W2328336468C98274493 @default.
- W2328336468 hasLocation W23283364681 @default.
- W2328336468 hasOpenAccess W2328336468 @default.
- W2328336468 hasPrimaryLocation W23283364681 @default.
- W2328336468 hasRelatedWork W1494961245 @default.
- W2328336468 hasRelatedWork W1536009245 @default.
- W2328336468 hasRelatedWork W1957646393 @default.
- W2328336468 hasRelatedWork W1978332925 @default.
- W2328336468 hasRelatedWork W2007790570 @default.
- W2328336468 hasRelatedWork W2016767359 @default.
- W2328336468 hasRelatedWork W2052529493 @default.
- W2328336468 hasRelatedWork W2097010522 @default.
- W2328336468 hasRelatedWork W2112035541 @default.
- W2328336468 hasRelatedWork W2113289062 @default.
- W2328336468 hasRelatedWork W2128910004 @default.
- W2328336468 hasRelatedWork W2142285790 @default.
- W2328336468 hasRelatedWork W2156912070 @default.
- W2328336468 hasRelatedWork W2156979835 @default.
- W2328336468 hasRelatedWork W2488944058 @default.
- W2328336468 hasRelatedWork W2516656370 @default.
- W2328336468 hasRelatedWork W2561600513 @default.
- W2328336468 hasRelatedWork W3147592117 @default.
- W2328336468 hasRelatedWork W1156156819 @default.
- W2328336468 hasRelatedWork W2594879304 @default.
- W2328336468 isParatext "false" @default.
- W2328336468 isRetracted "false" @default.
- W2328336468 magId "2328336468" @default.
- W2328336468 workType "article" @default.