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• W2328346880 abstract "The electron microscopic observation of pancreatic islets of normal and alloxan treated hypoglycemic rabbits yielded the following results.1. The elaboration of secretory granules by both A cells and B cells involves the activity of the rough endoplasmic reticulum and Golgi apparatus.2. The secretory granule of the A cell is released by emiocytosis.3. As to the release mechanism of the B granule, in addition to emiocytosis reported by several authors, the possibility of a diacrine type of secretion might be considered, especially under pathological conditions. It is suggested that alloxan might alter the limiting membrane of the B granules and the B cell plasma membrane to allow, by a pathological diacrine mechanism, the release of a large amount of insulin which causes the severe hypoglycemia after administration of this substance. In the experimental animal, the capillary endothelium becomes irregular in shape with numerous cytoplasmic processes and shows increase in the number of small vesicles suggesting the pinocytosis.4. The alloxan treated B cell containing empty granular sacs and relatively denser cytoplasmic matrix stains with aldehyde-thionine or aldehyde-fuchsin. It is obscure which causes this positive reaction, the empty sac or the hormonal substance diffused in the cytoplasmic matrix.5. The alloxan may alter not only the limiting membrane of the secretory granule but also the nucleus and cyto-organelles of the B cell, and thus disturb the formation of new secretory granules. Then the animal might become hyperglycemic because of the destruction of the B cell.6. The numerous cytoplasmic filaments found especially in the B cell seem to arise from free ribosomes or attached ribosomes of the outer nuclear membrane." @default.
• W2328346880 created "2016-06-24" @default.
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• W2328346880 date "1967-01-01" @default.
• W2328346880 modified "2023-10-18" @default.
• W2328346880 title "Some Observations on the Fine Structure of the Pancreatic Islet of Rabbits, with Special Reference to B Cell Alteration in the Hypoglycemic State Induced by Alloxan Treatment" @default.
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• W2328346880 doi "https://doi.org/10.1679/aohc1950.28.383" @default.
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