FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328347586> ?p ?o ?g. }

• W2328347586 endingPage "20" @default.
• W2328347586 startingPage "15" @default.
• W2328347586 abstract "C-fos is an immediate-early gene whose expression in the spinal cord has been extensively used as a marker of peripheral noxious stimulation. The Fos protein accumulates in the nuclei of spinal neurons, reaching detectable levels 2 h after stimulation. The ERK pathway is an important signalling pathway in spinal cord neurons. ERK is activated upon phosphorylation on specific amino acid residues. Its activation in the spinal cord, following noxious stimulation, has been shown to contribute to the establishment and maintenance of long-term neuronal alterations associated with chronic pain. Phosphorylated ERK can target several cellular elements, including transcription factors, which indicates that ERK participates in the regulation of gene expression. The relation between ERK and c-fos is at present still unclear. Some in vitro studies have reached the conclusion that ERK contributes to c-fos regulation whereas others have provided evidence of ERK-independent c-fos expression. In fact, in the spinal cord the occurrence of c-fos expression in the absence of ERK phosphorylation has been reported. In this study we investigated in vivo the contribution of ERK to c-fos expression in the spinal cord. By inhibiting spinal ERK activation with intrathecal administration of PD98059, we verified that ERK phosphorylation does contribute to regulate c-fos expression upon noxious bladder stimulation." @default.
• W2328347586 created "2016-06-24" @default.
• W2328347586 creator A5020370619 @default.
• W2328347586 creator A5036506943 @default.
• W2328347586 creator A5066120645 @default.
• W2328347586 creator A5075462647 @default.
• W2328347586 date "2007-01-01" @default.
• W2328347586 modified "2023-10-14" @default.
• W2328347586 title "The activation of the ERK pathway contributes to the spinal c-<i>fos</i>expression observed after noxious bladder stimulation" @default.
• W2328347586 cites W1520854803 @default.
• W2328347586 cites W1530030261 @default.
• W2328347586 cites W1568010017 @default.
• W2328347586 cites W1656928430 @default.
• W2328347586 cites W1784311570 @default.
• W2328347586 cites W1818221350 @default.
• W2328347586 cites W1821092064 @default.
• W2328347586 cites W1829029306 @default.
• W2328347586 cites W1919059205 @default.
• W2328347586 cites W1938895742 @default.
• W2328347586 cites W1975513971 @default.
• W2328347586 cites W2001026574 @default.
• W2328347586 cites W2003292663 @default.
• W2328347586 cites W2011353036 @default.
• W2328347586 cites W2017288998 @default.
• W2328347586 cites W2024762752 @default.
• W2328347586 cites W2032118701 @default.
• W2328347586 cites W2033402363 @default.
• W2328347586 cites W2035936653 @default.
• W2328347586 cites W2045745519 @default.
• W2328347586 cites W2046806142 @default.
• W2328347586 cites W2050196245 @default.
• W2328347586 cites W2069639395 @default.
• W2328347586 cites W2075708996 @default.
• W2328347586 cites W2079154359 @default.
• W2328347586 cites W2080289814 @default.
• W2328347586 cites W2081524299 @default.
• W2328347586 cites W2086196005 @default.
• W2328347586 cites W2087454739 @default.
• W2328347586 cites W2097593809 @default.
• W2328347586 cites W2103590789 @default.
• W2328347586 cites W2138435646 @default.
• W2328347586 cites W2140193821 @default.
• W2328347586 cites W2164180561 @default.
• W2328347586 cites W2164320803 @default.
• W2328347586 cites W4247904703 @default.
• W2328347586 doi "https://doi.org/10.1080/08990220601143265" @default.
• W2328347586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17558919" @default.
• W2328347586 hasPublicationYear "2007" @default.
• W2328347586 type Work @default.
• W2328347586 sameAs 2328347586 @default.
• W2328347586 citedByCount "26" @default.
• W2328347586 countsByYear W23283475862012 @default.
• W2328347586 countsByYear W23283475862016 @default.
• W2328347586 countsByYear W23283475862021 @default.
• W2328347586 crossrefType "journal-article" @default.
• W2328347586 hasAuthorship W2328347586A5020370619 @default.
• W2328347586 hasAuthorship W2328347586A5036506943 @default.
• W2328347586 hasAuthorship W2328347586A5066120645 @default.
• W2328347586 hasAuthorship W2328347586A5075462647 @default.
• W2328347586 hasConcept C104211972 @default.
• W2328347586 hasConcept C104317684 @default.
• W2328347586 hasConcept C11960822 @default.
• W2328347586 hasConcept C126322002 @default.
• W2328347586 hasConcept C150194340 @default.
• W2328347586 hasConcept C15490471 @default.
• W2328347586 hasConcept C169760540 @default.
• W2328347586 hasConcept C170493617 @default.
• W2328347586 hasConcept C185592680 @default.
• W2328347586 hasConcept C24998067 @default.
• W2328347586 hasConcept C2780323455 @default.
• W2328347586 hasConcept C2780775167 @default.
• W2328347586 hasConcept C55493867 @default.
• W2328347586 hasConcept C57074206 @default.
• W2328347586 hasConcept C71924100 @default.
• W2328347586 hasConcept C86803240 @default.
• W2328347586 hasConcept C95444343 @default.
• W2328347586 hasConceptScore W2328347586C104211972 @default.
• W2328347586 hasConceptScore W2328347586C104317684 @default.
• W2328347586 hasConceptScore W2328347586C11960822 @default.
• W2328347586 hasConceptScore W2328347586C126322002 @default.
• W2328347586 hasConceptScore W2328347586C150194340 @default.
• W2328347586 hasConceptScore W2328347586C15490471 @default.
• W2328347586 hasConceptScore W2328347586C169760540 @default.
• W2328347586 hasConceptScore W2328347586C170493617 @default.
• W2328347586 hasConceptScore W2328347586C185592680 @default.
• W2328347586 hasConceptScore W2328347586C24998067 @default.
• W2328347586 hasConceptScore W2328347586C2780323455 @default.
• W2328347586 hasConceptScore W2328347586C2780775167 @default.
• W2328347586 hasConceptScore W2328347586C55493867 @default.
• W2328347586 hasConceptScore W2328347586C57074206 @default.
• W2328347586 hasConceptScore W2328347586C71924100 @default.
• W2328347586 hasConceptScore W2328347586C86803240 @default.
• W2328347586 hasConceptScore W2328347586C95444343 @default.
• W2328347586 hasIssue "1-2" @default.
• W2328347586 hasLocation W23283475861 @default.
• W2328347586 hasLocation W23283475862 @default.
• W2328347586 hasOpenAccess W2328347586 @default.
• W2328347586 hasPrimaryLocation W23283475861 @default.

• next