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- W2328352782 endingPage "1135" @default.
- W2328352782 startingPage "1127" @default.
- W2328352782 abstract "Introduction: Toll-like receptors (TLRs) are expressed by a wide variety of cell types including immune cells. They play a crucial role in the inflammatory and host defense response against microorganisms, and triggering TLRs can mediate the activation of innate immunity. Furthermore, research suggests that various TLRs may function differently on different tumor cells. The change in TLR activity may elicit an anti-tumor activity in hepatocellular carcinoma (HCC) cells and may serve as a novel therapeutic target for HCC therapy.Areas covered: This review discusses the role of the TLR family in HCC and the underlying signaling pathway of TLRs as a form of pattern recognition receptor in mediating inflammation and HCC immunity responses. Agonists and antagonists of TLRs, which render TLRs as potential therapeutic targets, activate downstream molecules, subsequently causing HCC cell survival. The proliferation or protection against the development of HCC is also described.Expert opinion: A series of studies have highlighted a crucial role of TLRs in HCC and consider TLR signaling pathways as potential therapeutic targets for HCC. However, the conclusions of these studies are in part paradoxical and controversial. Thus, it is necessary to extend further research to help determine the signaling pathways involved." @default.
- W2328352782 created "2016-06-24" @default.
- W2328352782 creator A5000147534 @default.
- W2328352782 creator A5007591506 @default.
- W2328352782 creator A5025968595 @default.
- W2328352782 creator A5040253604 @default.
- W2328352782 creator A5043123531 @default.
- W2328352782 creator A5063298132 @default.
- W2328352782 date "2016-04-07" @default.
- W2328352782 modified "2023-10-06" @default.
- W2328352782 title "Toll-like receptors in hepatocellular carcinoma: potential novel targets for pharmacological intervention" @default.
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