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• W2328364630 abstract "The prevalence of antiphospholipid antibodies (aPL) and thrombophilic genotypes was compared and their reciprocal interactions assessed in consecutive patients with venous thrombosis (n = 101; 58 male, 43 female; mean age, 56 +/- 16 years) and in blood donors (n = 121; 55 male, 46 female; mean age, 43 +/- 12 years). Multiple aPL were detected by enzyme-linked immunosorbent assay (ELISA) and factor V Leiden (FVL), methylenetetrahydrofolate reductase (MTHFR) C677 <-- T and prothrombin (PT) G20210 <-- A by polymerase chain reaction. A pro-thrombotic state, including aPL, was found in 81% (82/101) of patients and 23% (29/121) of controls (P < 0.0001, odds ratio = 13.69, 95% confidence interval = 7.14-26.25). The prevalence of total aPL-positives was lower than MTHRF+/+ (homozygous state), FVL and PT G20210 <-- A (P < 0.0001) in the control group, but in line with the prevalence of total thrombophilic genotypes in the patient group: MTHFR+/+, 29%; FVL, 19%; PT, 14%; aPL, 20%. Having variously combined aPL and thrombophilic genotypes, only aPL remained as the most common pro-thrombotic factor in the patient group (P = 0.003). In patients without circumstantial factors for thrombosis, carriers of MTHFR+/+ + aPL showed a lower age at event than carriers of MTHFR+/+ alone or aPL alone (38 +/- 24 versus 65 +/- 10 years, P < 0.05 and 38 +/- 24 versus 63 +/- 16 years, P < 0.05, respectively). In the same patients, mean plasma homocysteine measured by an ELISA method was significantly higher in the MTHFR+/+ + aPL group than in the MTHFR+/+ alone or aPL alone groups (P = 0.01). Antiphospholipid antibodies are as common as thrombophilic genotypes in patients with venous thrombosis, and the interaction of aPL with MTHFR+/+ may influence age at first event via elevated plasma homocysteine." @default.
• W2328364630 created "2016-06-24" @default.
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• W2328364630 date "2001-12-01" @default.
• W2328364630 modified "2023-10-16" @default.
• W2328364630 title "Comparative prevalence of antiphospholipid antibodies and thrombophilic genotypes in consecutive patients with venous thrombosis" @default.
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• W2328364630 doi "https://doi.org/10.1097/00001721-200112000-00007" @default.
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