Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328390592> ?p ?o ?g. }
- W2328390592 endingPage "140" @default.
- W2328390592 startingPage "129" @default.
- W2328390592 abstract "The role of the ATP-binding cassette transporter 1 (ABCA1) in cellular lipid efflux and high density lipoprotein metabolism has been recently documented by mutations in genetic HDL deficiency syndromes such as classical Tangier disease. Analysis of ABCA1 knockout mice and overexpression studies have established the importance of ABCA1 as a major determinant of HDL cholesterol in plasma. These studies also indicate that ABCA1 is critically involved in cellular trafficking of cholesterol and choline-phospholipids and in total body lipid homeostasis, such as intestinal cholesterol and fat-soluble vitamin absorption and in the modulation of steroidogenesis. First insights into the upregulation of ABCA1 gene expression by cellular cholesterol and cAMP have identified critical ABCA1 promoter elements, which bind the transcription factors liver X receptor, retinoid X receptor, Sp1 and E-box proteins. The finding that a lipid sensitive subgroup of ABC transporters is able to translocate cholesterol and phospholipids supports the concept that in ABCA1 deficiency, compensatory mechanisms possibly involving MDR1, MDR3 and MRP-family members could be active. This suggests that a network of ABC transporters involved in cellular lipid transport exists, which is under the tight control of energy pathways directly linked to high density lipoprotein metabolism and atherogenesis." @default.
- W2328390592 created "2016-06-24" @default.
- W2328390592 creator A5052516859 @default.
- W2328390592 creator A5070833222 @default.
- W2328390592 date "2001-04-01" @default.
- W2328390592 modified "2023-10-01" @default.
- W2328390592 title "Structure, function and regulation of the ABC1 gene product" @default.
- W2328390592 cites W103569516 @default.
- W2328390592 cites W1494231874 @default.
- W2328390592 cites W1496990746 @default.
- W2328390592 cites W1549672253 @default.
- W2328390592 cites W1570388980 @default.
- W2328390592 cites W1591670239 @default.
- W2328390592 cites W1605020879 @default.
- W2328390592 cites W1607399348 @default.
- W2328390592 cites W1751757376 @default.
- W2328390592 cites W1860908381 @default.
- W2328390592 cites W1963898961 @default.
- W2328390592 cites W1967468249 @default.
- W2328390592 cites W1970325361 @default.
- W2328390592 cites W1970627731 @default.
- W2328390592 cites W1973195548 @default.
- W2328390592 cites W1974864595 @default.
- W2328390592 cites W1989188411 @default.
- W2328390592 cites W1991544676 @default.
- W2328390592 cites W1997720054 @default.
- W2328390592 cites W1998329673 @default.
- W2328390592 cites W2005427150 @default.
- W2328390592 cites W2007340378 @default.
- W2328390592 cites W2009436269 @default.
- W2328390592 cites W2009832539 @default.
- W2328390592 cites W2010824798 @default.
- W2328390592 cites W2011755553 @default.
- W2328390592 cites W2013557623 @default.
- W2328390592 cites W2016195347 @default.
- W2328390592 cites W2018513206 @default.
- W2328390592 cites W2019908728 @default.
- W2328390592 cites W2022110330 @default.
- W2328390592 cites W2022817398 @default.
- W2328390592 cites W2023345325 @default.
- W2328390592 cites W2023821585 @default.
- W2328390592 cites W2025159904 @default.
- W2328390592 cites W2031576290 @default.
- W2328390592 cites W2032513433 @default.
- W2328390592 cites W2033642373 @default.
- W2328390592 cites W2037103758 @default.
- W2328390592 cites W2037167329 @default.
- W2328390592 cites W2039171578 @default.
- W2328390592 cites W2043616397 @default.
- W2328390592 cites W2045622064 @default.
- W2328390592 cites W2047330360 @default.
- W2328390592 cites W2048397414 @default.
- W2328390592 cites W2049806370 @default.
- W2328390592 cites W2053365325 @default.
- W2328390592 cites W2055522214 @default.
- W2328390592 cites W2056452930 @default.
- W2328390592 cites W2066466374 @default.
- W2328390592 cites W2069540409 @default.
- W2328390592 cites W2073308465 @default.
- W2328390592 cites W2074888173 @default.
- W2328390592 cites W2075087933 @default.
- W2328390592 cites W2076546793 @default.
- W2328390592 cites W2077008338 @default.
- W2328390592 cites W2077760013 @default.
- W2328390592 cites W2082541003 @default.
- W2328390592 cites W2085909854 @default.
- W2328390592 cites W2087132954 @default.
- W2328390592 cites W2092974710 @default.
- W2328390592 cites W2093148729 @default.
- W2328390592 cites W2093296161 @default.
- W2328390592 cites W2099378835 @default.
- W2328390592 cites W2107272707 @default.
- W2328390592 cites W2107290681 @default.
- W2328390592 cites W2108150427 @default.
- W2328390592 cites W2108293406 @default.
- W2328390592 cites W2114270615 @default.
- W2328390592 cites W2119468178 @default.
- W2328390592 cites W2119803187 @default.
- W2328390592 cites W2120438776 @default.
- W2328390592 cites W2121668326 @default.
- W2328390592 cites W2121936687 @default.
- W2328390592 cites W2125422830 @default.
- W2328390592 cites W2127586864 @default.
- W2328390592 cites W2128986402 @default.
- W2328390592 cites W2129572698 @default.
- W2328390592 cites W2131451310 @default.
- W2328390592 cites W2134247450 @default.
- W2328390592 cites W2144693938 @default.
- W2328390592 cites W2144935194 @default.
- W2328390592 cites W2152919673 @default.
- W2328390592 cites W2157918748 @default.
- W2328390592 cites W2169542233 @default.
- W2328390592 cites W2170735211 @default.
- W2328390592 cites W2187039260 @default.
- W2328390592 cites W2188661295 @default.
- W2328390592 cites W2189552099 @default.
- W2328390592 cites W2239977054 @default.
- W2328390592 cites W4233108154 @default.