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- W2328408186 abstract "Background: Germline mutations in the RET protooncogene are associated with multiple endocrine neoplasia type 2 syndromes. The identification of individuals carrier of the mutated gene in MEN 2 kindreds by direct DNA analysis serves as the basis for prophylactic thyroidectomy. Methods: Genetic screening was performed by restriction enzyme analysis and DNA sequencing. Results: In 20 patients, who had inherited a mutation in the RET protooncogene, preoperative plasma calcitonin levels were normal in 10. Total thyroidectomy with median lymph node dissection and parathyroidectomy with autotransplantation were performed in all patients. The resected thyroid gland showed C-cell hyperplasia or medullary thyroid carcinoma in each patient. Conclusions: Direct DNA analysis enables the identification of asymptomatic carriers of the MEN type 2 syndromes. Prophylactic thyroidectomy can be performed while the C-cell disorder is in a curative stage." @default.
- W2328408186 created "2016-06-24" @default.
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- W2328408186 date "1997-01-01" @default.
- W2328408186 modified "2023-10-12" @default.
- W2328408186 title "Prophylactic thyroidectomy in MEN 2 gene carriers" @default.
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- W2328408186 doi "https://doi.org/10.1007/bf02620267" @default.
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