Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328443757> ?p ?o ?g. }
- W2328443757 endingPage "3188" @default.
- W2328443757 startingPage "3173" @default.
- W2328443757 abstract "Mice that carry a mutation in a calcium binding domain of Otoferlin, the putative calcium sensor at hair cell synapses, have normal distortion product otoacoustic emissions (DPOAEs), but auditory brain stem responses (ABRs) are absent. In mutant mice mechanotransduction is normal but transmission of acoustic information to the auditory pathway is blocked even before the onset of hearing. The cross-sectional area of the auditory nerve of mutant mice is reduced by 54%, and the volume of ventral cochlear nuclei is reduced by 46% relative to hearing control mice. While the tonotopic organization was not detectably changed in mutant mice, the axons to end bulbs of Held and the end bulbs themselves were smaller. In mutant mice bushy cells in the anteroventral cochlear nucleus (aVCN) have the electrophysiological hallmarks of control cells. Spontaneous miniature excitatory postsynaptic currents (EPSCs) occur with similar frequencies and have similar shapes in deaf as in hearing animals, but they are 24% larger in deaf mice. Bushy cells in deaf mutant mice are contacted by ∼2.6 auditory nerve fibers compared with ∼2.0 in hearing control mice. Furthermore, each fiber delivers more synaptic current, on average 4.8 nA compared with 3.4 nA, in deaf versus hearing control mice. The quantal content of evoked EPSCs is not different between mutant and control mice; the increase in synaptic current delivered in mutant mice is accounted for by the increased response to the size of the quanta. Although responses to shocks presented at long intervals are larger in mutant mice, they depress more rapidly than in hearing control mice." @default.
- W2328443757 created "2016-06-24" @default.
- W2328443757 creator A5000322821 @default.
- W2328443757 creator A5051424291 @default.
- W2328443757 creator A5089502097 @default.
- W2328443757 date "2014-12-15" @default.
- W2328443757 modified "2023-10-01" @default.
- W2328443757 title "Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin" @default.
- W2328443757 cites W1488984408 @default.
- W2328443757 cites W1515323557 @default.
- W2328443757 cites W1527023350 @default.
- W2328443757 cites W1545238849 @default.
- W2328443757 cites W1606945552 @default.
- W2328443757 cites W1644145788 @default.
- W2328443757 cites W1809106246 @default.
- W2328443757 cites W1840042507 @default.
- W2328443757 cites W1965234374 @default.
- W2328443757 cites W1966888567 @default.
- W2328443757 cites W1974711332 @default.
- W2328443757 cites W1974813892 @default.
- W2328443757 cites W1974935915 @default.
- W2328443757 cites W1975196303 @default.
- W2328443757 cites W1977456123 @default.
- W2328443757 cites W1980243386 @default.
- W2328443757 cites W1985004569 @default.
- W2328443757 cites W1986408320 @default.
- W2328443757 cites W1989280973 @default.
- W2328443757 cites W1992083670 @default.
- W2328443757 cites W1992961518 @default.
- W2328443757 cites W1997244273 @default.
- W2328443757 cites W1997759544 @default.
- W2328443757 cites W2000460311 @default.
- W2328443757 cites W2001002126 @default.
- W2328443757 cites W2002473366 @default.
- W2328443757 cites W2006623752 @default.
- W2328443757 cites W2007417371 @default.
- W2328443757 cites W2008305674 @default.
- W2328443757 cites W2009317697 @default.
- W2328443757 cites W2010225357 @default.
- W2328443757 cites W2010887299 @default.
- W2328443757 cites W2011420265 @default.
- W2328443757 cites W2011889205 @default.
- W2328443757 cites W2013521212 @default.
- W2328443757 cites W2021314608 @default.
- W2328443757 cites W2023474594 @default.
- W2328443757 cites W2025072189 @default.
- W2328443757 cites W2026593185 @default.
- W2328443757 cites W2026621660 @default.
- W2328443757 cites W2028665411 @default.
- W2328443757 cites W2030435568 @default.
- W2328443757 cites W2033347933 @default.
- W2328443757 cites W2033590888 @default.
- W2328443757 cites W2044797107 @default.
- W2328443757 cites W2050923395 @default.
- W2328443757 cites W2053652256 @default.
- W2328443757 cites W2057229298 @default.
- W2328443757 cites W2058970778 @default.
- W2328443757 cites W2059419535 @default.
- W2328443757 cites W2063062105 @default.
- W2328443757 cites W2063100675 @default.
- W2328443757 cites W2064728764 @default.
- W2328443757 cites W2068118330 @default.
- W2328443757 cites W2073188416 @default.
- W2328443757 cites W2074154700 @default.
- W2328443757 cites W2076301840 @default.
- W2328443757 cites W2078577861 @default.
- W2328443757 cites W2079828414 @default.
- W2328443757 cites W2080033848 @default.
- W2328443757 cites W2080625834 @default.
- W2328443757 cites W2081859390 @default.
- W2328443757 cites W2085124610 @default.
- W2328443757 cites W2086210608 @default.
- W2328443757 cites W2088853309 @default.
- W2328443757 cites W2091869150 @default.
- W2328443757 cites W2093522628 @default.
- W2328443757 cites W2093605386 @default.
- W2328443757 cites W2098807103 @default.
- W2328443757 cites W2100619983 @default.
- W2328443757 cites W2104737125 @default.
- W2328443757 cites W2110381749 @default.
- W2328443757 cites W2110826992 @default.
- W2328443757 cites W2112923982 @default.
- W2328443757 cites W2114309709 @default.
- W2328443757 cites W2116477192 @default.
- W2328443757 cites W2119190060 @default.
- W2328443757 cites W2122358271 @default.
- W2328443757 cites W2128292852 @default.
- W2328443757 cites W2128556377 @default.
- W2328443757 cites W2133254036 @default.
- W2328443757 cites W2139238682 @default.
- W2328443757 cites W2142997504 @default.
- W2328443757 cites W2144675138 @default.
- W2328443757 cites W2145935221 @default.
- W2328443757 cites W2146723580 @default.
- W2328443757 cites W2153499119 @default.
- W2328443757 cites W2159667989 @default.
- W2328443757 cites W2160763011 @default.
- W2328443757 cites W2161798491 @default.