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• W2328494684 abstract "As the clinical use of biologic response modifiers continues to increase, the old way of estimating effective doses in oncology, i.e. reaching dose-limiting toxicities, is becoming obsolete. Biologic response modifiers and targeted therapies are less toxic and their effective dose is often left shifted on the dose response curve. This is why the majority of pharmaceutical companies have opened new programs seeking biomarker of therapeutic response, and why numerous research programs have been announcing Request for Applications in order to find and evaluate biomarkers of disease. Because of the ease of procurement of the clinical specimen, plasma and serum, remain the favorite clinical analytes. However, the sheer numbers of different plasma proteins, the many thousand fold differences in the amounts of the potential protein biomarkers, and the lack of specificity of plasma proteins have hindered the search. The ability to detect changes in the levels of proteins expressed in picomolar quantities are mired by the presence of more abundant nonspecific proteins such as albumin or immunoglobulins. Most meaningful changes, those that occur in the amounts of free proteins, remain very difficult to evaluate. The recent discovery that angiogenesis regulators are actively and selectively sequestered in platelets early in cancer, has led to renewed hopes of finding circulating biomarkers that would help in early disease detection, and improve our ability to detect an early therapeutic response. There are early indicators that this is the case in other diseases as well, and that the focus may be shifting from analyzing plasma and serum, to analyzing platelets. Keywords: Angiogenesis, early tumor detection, platelet, platelet biomarkers, proteomics, cancer growth, diabetic retinopathy, endometriosis, atherosclerosis, rheumatoid arthritis, psoriasis, metastasis, autism, schizophrenia, asthma" @default.
• W2328494684 created "2016-06-24" @default.
• W2328494684 creator A5035228727 @default.
• W2328494684 date "2011-10-01" @default.
• W2328494684 modified "2023-10-17" @default.
• W2328494684 title "Platelet Biomarkers in Tumor Growth" @default.
• W2328494684 cites W1265988497 @default.
• W2328494684 cites W1338787 @default.
• W2328494684 cites W135839998 @default.
• W2328494684 cites W1529752909 @default.
• W2328494684 cites W1536258113 @default.
• W2328494684 cites W1585437324 @default.
• W2328494684 cites W1590155607 @default.
• W2328494684 cites W1601527918 @default.
• W2328494684 cites W1608780962 @default.
• W2328494684 cites W1975021346 @default.
• W2328494684 cites W1976160855 @default.
• W2328494684 cites W1976697969 @default.
• W2328494684 cites W1978943601 @default.
• W2328494684 cites W1979679866 @default.
• W2328494684 cites W1979960383 @default.
• W2328494684 cites W1983822368 @default.
• W2328494684 cites W1986540698 @default.
• W2328494684 cites W1990770540 @default.
• W2328494684 cites W1995601334 @default.
• W2328494684 cites W1995954397 @default.
• W2328494684 cites W1997719795 @default.
• W2328494684 cites W1997919707 @default.
• W2328494684 cites W2002215005 @default.
• W2328494684 cites W2003419989 @default.
• W2328494684 cites W2003632052 @default.
• W2328494684 cites W2005068407 @default.
• W2328494684 cites W2010851239 @default.
• W2328494684 cites W2013813279 @default.
• W2328494684 cites W2016725226 @default.
• W2328494684 cites W2017236917 @default.
• W2328494684 cites W2018076208 @default.
• W2328494684 cites W2019586037 @default.
• W2328494684 cites W2021000992 @default.
• W2328494684 cites W2021036829 @default.
• W2328494684 cites W2022692034 @default.
• W2328494684 cites W2022725096 @default.
• W2328494684 cites W2024892254 @default.
• W2328494684 cites W2026651252 @default.
• W2328494684 cites W2027417871 @default.
• W2328494684 cites W2028031291 @default.
• W2328494684 cites W2028087310 @default.
• W2328494684 cites W2032887833 @default.
• W2328494684 cites W2037136309 @default.
• W2328494684 cites W2037591080 @default.
• W2328494684 cites W2038327247 @default.
• W2328494684 cites W2038475449 @default.
• W2328494684 cites W2039045714 @default.
• W2328494684 cites W2041985606 @default.
• W2328494684 cites W2042267614 @default.
• W2328494684 cites W2046651900 @default.
• W2328494684 cites W2047418944 @default.
• W2328494684 cites W2048538454 @default.
• W2328494684 cites W2049716477 @default.
• W2328494684 cites W2050954989 @default.
• W2328494684 cites W2050992261 @default.
• W2328494684 cites W2052492883 @default.
• W2328494684 cites W2056681665 @default.
• W2328494684 cites W2056831231 @default.
• W2328494684 cites W2057688862 @default.
• W2328494684 cites W2060865357 @default.
• W2328494684 cites W2061341372 @default.
• W2328494684 cites W2062948597 @default.
• W2328494684 cites W2067961316 @default.
• W2328494684 cites W2068773189 @default.
• W2328494684 cites W2069363135 @default.
• W2328494684 cites W2070566769 @default.
• W2328494684 cites W2073893857 @default.
• W2328494684 cites W2074859138 @default.
• W2328494684 cites W2079402113 @default.
• W2328494684 cites W2079989335 @default.
• W2328494684 cites W2080565891 @default.
• W2328494684 cites W2083045535 @default.
• W2328494684 cites W2088001386 @default.
• W2328494684 cites W2091451081 @default.
• W2328494684 cites W2091493430 @default.
• W2328494684 cites W2092352455 @default.
• W2328494684 cites W2093498435 @default.
• W2328494684 cites W2094777896 @default.
• W2328494684 cites W2097414678 @default.
• W2328494684 cites W2101681003 @default.
• W2328494684 cites W2102541302 @default.
• W2328494684 cites W2107067281 @default.
• W2328494684 cites W2108269810 @default.
• W2328494684 cites W2110421721 @default.
• W2328494684 cites W2111139930 @default.
• W2328494684 cites W2112285684 @default.
• W2328494684 cites W2118683216 @default.
• W2328494684 cites W2120587170 @default.
• W2328494684 cites W2120863072 @default.
• W2328494684 cites W2122430069 @default.
• W2328494684 cites W2123399862 @default.
• W2328494684 cites W2124084066 @default.

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