FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328504392> ?p ?o ?g. }

• W2328504392 endingPage "20" @default.
• W2328504392 startingPage "20" @default.
• W2328504392 abstract "Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe disease." @default.
• W2328504392 created "2016-06-24" @default.
• W2328504392 creator A5000610415 @default.
• W2328504392 creator A5005940571 @default.
• W2328504392 creator A5008047924 @default.
• W2328504392 creator A5020173949 @default.
• W2328504392 creator A5022138320 @default.
• W2328504392 creator A5029403669 @default.
• W2328504392 creator A5033033796 @default.
• W2328504392 creator A5035694502 @default.
• W2328504392 creator A5041435505 @default.
• W2328504392 creator A5045851589 @default.
• W2328504392 creator A5047947605 @default.
• W2328504392 creator A5048716954 @default.
• W2328504392 date "2014-01-01" @default.
• W2328504392 modified "2023-09-27" @default.
• W2328504392 title "Role of β-microseminoprotein from prostate cancer initiation to recurrence: A mini-review" @default.
• W2328504392 cites W121060991 @default.
• W2328504392 cites W1550319538 @default.
• W2328504392 cites W1608106982 @default.
• W2328504392 cites W1753475264 @default.
• W2328504392 cites W1780894513 @default.
• W2328504392 cites W1918654887 @default.
• W2328504392 cites W1921660070 @default.
• W2328504392 cites W1932417500 @default.
• W2328504392 cites W1964043391 @default.
• W2328504392 cites W1965244294 @default.
• W2328504392 cites W1967788599 @default.
• W2328504392 cites W1970757301 @default.
• W2328504392 cites W1972788786 @default.
• W2328504392 cites W1973059882 @default.
• W2328504392 cites W1974840641 @default.
• W2328504392 cites W1975423257 @default.
• W2328504392 cites W1977546001 @default.
• W2328504392 cites W1978751114 @default.
• W2328504392 cites W1979693703 @default.
• W2328504392 cites W1979940427 @default.
• W2328504392 cites W1993556734 @default.
• W2328504392 cites W1999383800 @default.
• W2328504392 cites W2001388224 @default.
• W2328504392 cites W2004054644 @default.
• W2328504392 cites W2011875227 @default.
• W2328504392 cites W2012739442 @default.
• W2328504392 cites W2013247951 @default.
• W2328504392 cites W2016381427 @default.
• W2328504392 cites W2018235438 @default.
• W2328504392 cites W2018632596 @default.
• W2328504392 cites W2023887187 @default.
• W2328504392 cites W2024097324 @default.
• W2328504392 cites W2027014013 @default.
• W2328504392 cites W2028356987 @default.
• W2328504392 cites W2028853380 @default.
• W2328504392 cites W2029628988 @default.
• W2328504392 cites W2031495078 @default.
• W2328504392 cites W2033874919 @default.
• W2328504392 cites W2034368665 @default.
• W2328504392 cites W2038700261 @default.
• W2328504392 cites W2041473546 @default.
• W2328504392 cites W2044757108 @default.
• W2328504392 cites W2047200356 @default.
• W2328504392 cites W2049598073 @default.
• W2328504392 cites W2050182534 @default.
• W2328504392 cites W2052642928 @default.
• W2328504392 cites W2053007597 @default.
• W2328504392 cites W2060336321 @default.
• W2328504392 cites W2065219066 @default.
• W2328504392 cites W2068412840 @default.
• W2328504392 cites W2071533775 @default.
• W2328504392 cites W2071934266 @default.
• W2328504392 cites W2072281435 @default.
• W2328504392 cites W2073942944 @default.
• W2328504392 cites W2075122750 @default.
• W2328504392 cites W2075302864 @default.
• W2328504392 cites W2076280242 @default.
• W2328504392 cites W2077301757 @default.
• W2328504392 cites W2080071903 @default.
• W2328504392 cites W2085109442 @default.
• W2328504392 cites W2088522662 @default.
• W2328504392 cites W2089800336 @default.
• W2328504392 cites W2097265742 @default.
• W2328504392 cites W2097444820 @default.
• W2328504392 cites W2101858552 @default.
• W2328504392 cites W2108165834 @default.
• W2328504392 cites W2109502519 @default.
• W2328504392 cites W2109600639 @default.
• W2328504392 cites W2111788559 @default.
• W2328504392 cites W2112601799 @default.
• W2328504392 cites W2112856704 @default.
• W2328504392 cites W2129606333 @default.
• W2328504392 cites W2135457855 @default.
• W2328504392 cites W2136608299 @default.
• W2328504392 cites W2141698087 @default.
• W2328504392 cites W2143025126 @default.
• W2328504392 cites W2146499878 @default.
• W2328504392 cites W2157220925 @default.
• W2328504392 cites W2158944729 @default.
• W2328504392 cites W2253092980 @default.
• W2328504392 cites W2318044823 @default.

• next