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- W2328507304 abstract "BACKGROUND Heart failure (HF) is characterized by neurohormonal activation of sympathetic nervous and renin-angiotensin systems. We tested whether genetic polymorphisms in these systems are associated with death or heart transplantation in patients with HF. METHODS 227 HF patients were enrolled from a tertiary care HF clinic and followed for outcomes every 6 months for up to 4 years. We genotyped 8 polymorphisms in 6 genes including: β1 adrenergic receptor (ADRB1, S49G and R389G), β2 adrenergic receptor (ADRB2, G16R and Q27E), α2c adrenergic receptor (ADRA2C, Insertion/Deletion (I/D) 322–325), angiotensinogen (AGT, M235T), angiotensin receptor type 1 (AGTR1, A1166C), and angiotensin converting enzyme (ACE, I/D in intron 16). HAP software was used for haplotype assignment for ADRB1 and ADRB2. Cox proportional hazard regression was performed to model the outcomes with genotypes/haplotypes, adjusting for non-genetic predictors of HF. RESULTS During a median 2.5 year follow-up period, 78 patients had an adverse outcome. Ninety five percent and 81% of the patients received an ACE inhibitor/angiotensin receptor blocker and a β-blocker at baseline, respectively. Significant predictors are shown in the Table. The ADRB2 RQ haplotype was the only genotype/haplotype associated with adverse outcomes. Variable Hazard ratio 95% confidence interval P-value NYHA class 2.56 1.84–3.56 <0.0001 Creatinine clearance 0.99 0.98–0.99 0.0016 Sodium 0.91 0.86–0.97 0.0019 Male gender 2.33 1.33–4.10 0.0032 ADRB2 RQ haplotype 1.40 1.01–1.93 0.047 CONCLUSIONS In addition to other traditional predictors, ADRB2 haplotype may have a significant effect on risk for heart transplant/death in HF patients who receive contemporary HF pharmacotherapy. Clinical Pharmacology & Therapeutics (2005) 79, P30–P30; doi: 10.1016/j.clpt.2005.12.111" @default.
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- W2328507304 date "2006-02-01" @default.
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- W2328507304 title "OIII-B-2A haplotype of β2-adrenoceptor is associated with the increased risk for transplant or death in heart failure patients" @default.
- W2328507304 doi "https://doi.org/10.1016/j.clpt.2005.12.111" @default.
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