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- W2328534180 abstract "A series of 17-succinyl derivatives of four corticosteroids was prepared. They were tested for vasoconstrictive activity in humans, using 9α-fluoro-11β, 21-dihydroxy-16β-methyl-17α-valeryloxy-1, 4-pregnediene-3, 20-dione (betamethasone 17-valerate, BV) as a standard. The activities of the 21-chloro 17-methylsuccinate compounds (6A, 6C and 6D) were greater than that of BV. A structure-activity relationship study showed that the activities of the 21-chloro 17-methylsuccinates were more potent than those of the corresponding 21-esters." @default.
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- W2328534180 date "1989-01-01" @default.
- W2328534180 modified "2023-09-24" @default.
- W2328534180 title "Studies on topical antiinflammatory agents. I. Synthesis and vasoconstrictive activity of corticosteroid 17-succinyl esters." @default.
- W2328534180 doi "https://doi.org/10.1248/cpb.37.1534" @default.
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