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- W2328559660 endingPage "15438" @default.
- W2328559660 startingPage "15430" @default.
- W2328559660 abstract "The reactions of uric and 1-methyluric acids in nonpolar environments, as well as those of the corresponding urate anions in aqueous solution, with •OH, •OCH3, •OOH, and •OOCH3 have been studied using the density functional theory. Different mechanisms of reactions have been taken into account, and their relative importance on the antiradical activity of these compounds is analyzed. Both uric and methyluric acids are better scavengers in aqueous solution than in nonpolar media, which indicates that the urate anions are the most active species. The free radical scavenging activity of the studied compounds was found to be excellent for •OH, and very good for •OCH3. In addition, 1-methyluric acid is predicted to moderately protect against peroxyl oxidation, while the protective effects of uric acid against these particular species are not expected to be significant. In addition, 1-methyluric acid was found to be a better radical scavenger than its precursor, caffeine, suggesting that the antiradical activity of the latter might be explained by the action of its metabolites, rather than by its direct activity." @default.
- W2328559660 created "2016-06-24" @default.
- W2328559660 creator A5053156610 @default.
- W2328559660 creator A5065336088 @default.
- W2328559660 date "2011-12-05" @default.
- W2328559660 modified "2023-10-18" @default.
- W2328559660 title "Uric and 1-Methyluric Acids: Metabolic Wastes or Antiradical Protectors?" @default.
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