FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328614464> ?p ?o ?g. }

• W2328614464 abstract "To evaluate reverse 3,3',5'-triiodothyronine (rT3) metabolism in nephrotic syndrome, serum rT3 kinetic studies from 10 nephrotics (mean urinary protein losses 7.0 g/day) with normal glomerular filtration rates (GFR; creatinine clearance 107 ml/min) were compared with 9 normal healthy subjects. Serum disappearance data were analyzed in a three-pool model, including rapidly (liver and kidney) and slowly (muscle, skin, and brain) equilibrating pools exchanging with serum, with all losses from the rapidly equilibrating pool. Serum free thyroxine (T4), determined by equilibrium dialysis, and parathyroid hormone levels were unaltered; total T4, T3, and rT3, and free rT3, albumin, and transferrin levels were significantly decreased; and free fractions of T4 and rT3 and thyroid-stimulating hormone (TSH) levels were increased. Despite reduced rT3 binding in serum, fractional transfer rates from serum to extravascular sites and serum clearance rates of total rT3 were unaltered. Free hormone clearance, serum appearance, and maximum hormone production rates were decreased. Total hormone transfer rates between serum and tissue pools and rT3 mass in serum and both tissue pools were reduced. Binding in the slowly equilibrating pool was decreased, and binding in both rapidly and slowly equilibrating pools was correlated with the free fraction of rT3 (r = -0.79, P = 0.007, and r = -0.70, P less than 0.025, respectively), with a shift of rT3 from the slow to the rapid pool. These findings suggest that binding of rT3 and T4 to serum carrier proteins is reduced, the transfer process for rT3 from serum to extravascular sites is decreased by factors in addition to reduced serum binding, degradation of rT3 is impaired, and decreased slow-pool binding may reflect reduced rT3 binding to serum-derived proteins in interstitial fluid. Furthermore, rT3 production rates are reduced, despite normal serum free T4 levels, accounting for low serum free rT3 concentrations. Total rT3 levels are decreased because of decrements in both serum binding and production rates." @default.
• W2328614464 created "2016-06-24" @default.
• W2328614464 creator A5005395654 @default.
• W2328614464 creator A5012561025 @default.
• W2328614464 creator A5063237643 @default.
• W2328614464 creator A5077961892 @default.
• W2328614464 date "1991-04-01" @default.
• W2328614464 modified "2023-09-27" @default.
• W2328614464 title "rT3 metabolism in patients with nephrotic syndrome and normal GFR compared with normal subjects" @default.
• W2328614464 cites W1550422636 @default.
• W2328614464 cites W1976343441 @default.
• W2328614464 cites W1998437047 @default.
• W2328614464 cites W1999408599 @default.
• W2328614464 cites W2008718385 @default.
• W2328614464 cites W2011274573 @default.
• W2328614464 cites W2020830596 @default.
• W2328614464 cites W2036259344 @default.
• W2328614464 cites W2042661907 @default.
• W2328614464 cites W2047209196 @default.
• W2328614464 cites W2050844552 @default.
• W2328614464 cites W2054780829 @default.
• W2328614464 cites W2064799388 @default.
• W2328614464 cites W2066358728 @default.
• W2328614464 cites W2067248957 @default.
• W2328614464 cites W2071014266 @default.
• W2328614464 cites W2076766109 @default.
• W2328614464 cites W2089505665 @default.
• W2328614464 cites W2091894154 @default.
• W2328614464 cites W2108230614 @default.
• W2328614464 cites W2114867773 @default.
• W2328614464 cites W2150365860 @default.
• W2328614464 cites W2157431868 @default.
• W2328614464 cites W2158992700 @default.
• W2328614464 cites W2412133288 @default.
• W2328614464 doi "https://doi.org/10.1152/ajpendo.1991.260.4.e641" @default.
• W2328614464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2018127" @default.
• W2328614464 hasPublicationYear "1991" @default.
• W2328614464 type Work @default.
• W2328614464 sameAs 2328614464 @default.
• W2328614464 citedByCount "6" @default.
• W2328614464 countsByYear W23286144642013 @default.
• W2328614464 countsByYear W23286144642014 @default.
• W2328614464 countsByYear W23286144642021 @default.
• W2328614464 crossrefType "journal-article" @default.
• W2328614464 hasAuthorship W2328614464A5005395654 @default.
• W2328614464 hasAuthorship W2328614464A5012561025 @default.
• W2328614464 hasAuthorship W2328614464A5063237643 @default.
• W2328614464 hasAuthorship W2328614464A5077961892 @default.
• W2328614464 hasConcept C112705442 @default.
• W2328614464 hasConcept C126322002 @default.
• W2328614464 hasConcept C134018914 @default.
• W2328614464 hasConcept C159641895 @default.
• W2328614464 hasConcept C165616093 @default.
• W2328614464 hasConcept C185592680 @default.
• W2328614464 hasConcept C22814914 @default.
• W2328614464 hasConcept C2776125364 @default.
• W2328614464 hasConcept C2778288131 @default.
• W2328614464 hasConcept C2778930706 @default.
• W2328614464 hasConcept C2780306776 @default.
• W2328614464 hasConcept C2780486670 @default.
• W2328614464 hasConcept C2781233306 @default.
• W2328614464 hasConcept C62231903 @default.
• W2328614464 hasConcept C71315377 @default.
• W2328614464 hasConcept C71924100 @default.
• W2328614464 hasConcept C81358767 @default.
• W2328614464 hasConcept C86803240 @default.
• W2328614464 hasConceptScore W2328614464C112705442 @default.
• W2328614464 hasConceptScore W2328614464C126322002 @default.
• W2328614464 hasConceptScore W2328614464C134018914 @default.
• W2328614464 hasConceptScore W2328614464C159641895 @default.
• W2328614464 hasConceptScore W2328614464C165616093 @default.
• W2328614464 hasConceptScore W2328614464C185592680 @default.
• W2328614464 hasConceptScore W2328614464C22814914 @default.
• W2328614464 hasConceptScore W2328614464C2776125364 @default.
• W2328614464 hasConceptScore W2328614464C2778288131 @default.
• W2328614464 hasConceptScore W2328614464C2778930706 @default.
• W2328614464 hasConceptScore W2328614464C2780306776 @default.
• W2328614464 hasConceptScore W2328614464C2780486670 @default.
• W2328614464 hasConceptScore W2328614464C2781233306 @default.
• W2328614464 hasConceptScore W2328614464C62231903 @default.
• W2328614464 hasConceptScore W2328614464C71315377 @default.
• W2328614464 hasConceptScore W2328614464C71924100 @default.
• W2328614464 hasConceptScore W2328614464C81358767 @default.
• W2328614464 hasConceptScore W2328614464C86803240 @default.
• W2328614464 hasLocation W23286144641 @default.
• W2328614464 hasLocation W23286144642 @default.
• W2328614464 hasOpenAccess W2328614464 @default.
• W2328614464 hasPrimaryLocation W23286144641 @default.
• W2328614464 hasRelatedWork W2037906920 @default.
• W2328614464 hasRelatedWork W2041345005 @default.
• W2328614464 hasRelatedWork W2061866409 @default.
• W2328614464 hasRelatedWork W2065409034 @default.
• W2328614464 hasRelatedWork W2067637914 @default.
• W2328614464 hasRelatedWork W2070480234 @default.
• W2328614464 hasRelatedWork W2075256037 @default.
• W2328614464 hasRelatedWork W2106687377 @default.
• W2328614464 hasRelatedWork W2118001750 @default.
• W2328614464 hasRelatedWork W2328614464 @default.
• W2328614464 isParatext "false" @default.
• W2328614464 isRetracted "false" @default.

• next