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- W2328651485 abstract "A systematic study on pharmacokinetcs and tissue distribution of danshensu (one of the major active components from Salvia miltiorrhiza) is conducted using a rapid and sensitive highperformance liquid chromatographic (HPLC) method. Before HPLC analysis, biological samples are pretreated with a liquid-liquid extraction. Separation of danshensu and internal standard is achieved on an Agilent Zorbax C18 column with a mobile phase made up of acetonitrile and 0.05% trifluoracetic acid at a flow rate of 0.8 mL/min. The calibration curves in plasma and tissues are linear in the given concentration ranges, with r2 no less than 0.99. The intra-day and inter-day relative standard deviations in the measurement of quality control samples are less than 15%, and the accuracies are in the range of 86–115%. The recoveries of danshensu in plasma and tissues are among 80% to 118%. Meanwhile, the multi-peaks in pharmacokinetic profiles are observed. The method is successfully applied to the pharmacokinetics and tissue distribution study of danshensu after a single oral administration of 50.0 mg/kg sodium danshensu to rats." @default.
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- W2328651485 date "2008-02-01" @default.
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- W2328651485 title "Determination of Danshensu in Rat Plasma and Tissues by High-Performance Liquid Chromatography" @default.
- W2328651485 doi "https://doi.org/10.1093/chromsci/46.2.184" @default.
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