FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328653670> ?p ?o ?g. }

• W2328653670 endingPage "663" @default.
• W2328653670 startingPage "656" @default.
• W2328653670 abstract "Cancer/testis antigen HCA587/MAGE-C2 has been considered as a tumor specific target for immunotherapy. It has been reported that HCA587/MAGE-C2 plays an active role in tumorigenesis by promoting the growth and survival of tumor cells. However, the regulation of HCA587/MAGE-C2 expression in cancer cells remains largely unknown. MicroRNAs (miRNAs), a large family of gene regulators, have been shown to negatively regulate the expression of important cancer-related genes and contribute to the initiation and development of cancers. In this study, we conducted searches of miRNAs that regulate HCA587/MAGE-C2 expression. We combined bioinformatics tools with biological validation assays to demonstrate that HCA587/MAGE-C2 is a direct target of microRNA-874 (miR-874). Furthermore, we investigated the expression levels of miR-874 in human hepatocellular carcinoma tissues and paired adjacent normal tissues by stem-loop reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The results revealed a significant downregulation of miR-874 expression in tumor tissues compared to adjacent normal tissues. Finally, we demonstrated that overexpression of miR-874, as well as HCA587/MAGE-C2 silencing, resulted in suppression of tumor cell proliferation and invasion. Moreover, the inhibition effects of miR-874 on cell proliferation and invasion were reversed by co-expression of HCA587/MAGE-C2 in A375 cells. Taken together, our data demonstrated that HCA587/MAGE-C2 is a direct target of miR-874, and miR-874 may function as a tumor suppressive miRNA, at least in part, by negatively regulating HCA587/MAGE-C2 expression in cancer cells." @default.
• W2328653670 created "2016-06-24" @default.
• W2328653670 creator A5000095164 @default.
• W2328653670 creator A5016245266 @default.
• W2328653670 creator A5018863416 @default.
• W2328653670 creator A5021749487 @default.
• W2328653670 creator A5029040210 @default.
• W2328653670 creator A5032337609 @default.
• W2328653670 creator A5067221645 @default.
• W2328653670 creator A5071574564 @default.
• W2328653670 creator A5071773009 @default.
• W2328653670 date "2016-01-01" @default.
• W2328653670 modified "2023-10-16" @default.
• W2328653670 title "MicroRNA-874 Functions as a Tumor Suppressor by Targeting Cancer/Testis Antigen HCA587/MAGE-C2" @default.
• W2328653670 cites W144423133 @default.
• W2328653670 cites W1603340288 @default.
• W2328653670 cites W1608820529 @default.
• W2328653670 cites W1648301895 @default.
• W2328653670 cites W1975437957 @default.
• W2328653670 cites W1981417548 @default.
• W2328653670 cites W1985563073 @default.
• W2328653670 cites W1986592841 @default.
• W2328653670 cites W1986814961 @default.
• W2328653670 cites W1991168811 @default.
• W2328653670 cites W1996818255 @default.
• W2328653670 cites W1998074925 @default.
• W2328653670 cites W1999811708 @default.
• W2328653670 cites W2002995168 @default.
• W2328653670 cites W2007099933 @default.
• W2328653670 cites W2007655132 @default.
• W2328653670 cites W2016708274 @default.
• W2328653670 cites W2027895126 @default.
• W2328653670 cites W2030049178 @default.
• W2328653670 cites W2055050962 @default.
• W2328653670 cites W2056851405 @default.
• W2328653670 cites W2058545076 @default.
• W2328653670 cites W2070032866 @default.
• W2328653670 cites W2083975873 @default.
• W2328653670 cites W2086762172 @default.
• W2328653670 cites W2086856480 @default.
• W2328653670 cites W2086882683 @default.
• W2328653670 cites W2095501304 @default.
• W2328653670 cites W2098357256 @default.
• W2328653670 cites W2101659058 @default.
• W2328653670 cites W2135314242 @default.
• W2328653670 cites W2142190430 @default.
• W2328653670 cites W2149146453 @default.
• W2328653670 cites W2150536104 @default.
• W2328653670 cites W2157352980 @default.
• W2328653670 cites W2597632520 @default.
• W2328653670 doi "https://doi.org/10.7150/jca.13674" @default.
• W2328653670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4829551" @default.
• W2328653670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27076846" @default.
• W2328653670 hasPublicationYear "2016" @default.
• W2328653670 type Work @default.
• W2328653670 sameAs 2328653670 @default.
• W2328653670 citedByCount "19" @default.
• W2328653670 countsByYear W23286536702017 @default.
• W2328653670 countsByYear W23286536702018 @default.
• W2328653670 countsByYear W23286536702019 @default.
• W2328653670 countsByYear W23286536702020 @default.
• W2328653670 countsByYear W23286536702021 @default.
• W2328653670 countsByYear W23286536702022 @default.
• W2328653670 crossrefType "journal-article" @default.
• W2328653670 hasAuthorship W2328653670A5000095164 @default.
• W2328653670 hasAuthorship W2328653670A5016245266 @default.
• W2328653670 hasAuthorship W2328653670A5018863416 @default.
• W2328653670 hasAuthorship W2328653670A5021749487 @default.
• W2328653670 hasAuthorship W2328653670A5029040210 @default.
• W2328653670 hasAuthorship W2328653670A5032337609 @default.
• W2328653670 hasAuthorship W2328653670A5067221645 @default.
• W2328653670 hasAuthorship W2328653670A5071574564 @default.
• W2328653670 hasAuthorship W2328653670A5071773009 @default.
• W2328653670 hasBestOaLocation W23286536701 @default.
• W2328653670 hasConcept C104317684 @default.
• W2328653670 hasConcept C119056186 @default.
• W2328653670 hasConcept C121608353 @default.
• W2328653670 hasConcept C127561419 @default.
• W2328653670 hasConcept C145059251 @default.
• W2328653670 hasConcept C179185449 @default.
• W2328653670 hasConcept C502942594 @default.
• W2328653670 hasConcept C54355233 @default.
• W2328653670 hasConcept C555283112 @default.
• W2328653670 hasConcept C62112901 @default.
• W2328653670 hasConcept C86803240 @default.
• W2328653670 hasConceptScore W2328653670C104317684 @default.
• W2328653670 hasConceptScore W2328653670C119056186 @default.
• W2328653670 hasConceptScore W2328653670C121608353 @default.
• W2328653670 hasConceptScore W2328653670C127561419 @default.
• W2328653670 hasConceptScore W2328653670C145059251 @default.
• W2328653670 hasConceptScore W2328653670C179185449 @default.
• W2328653670 hasConceptScore W2328653670C502942594 @default.
• W2328653670 hasConceptScore W2328653670C54355233 @default.
• W2328653670 hasConceptScore W2328653670C555283112 @default.
• W2328653670 hasConceptScore W2328653670C62112901 @default.
• W2328653670 hasConceptScore W2328653670C86803240 @default.
• W2328653670 hasIssue "6" @default.
• W2328653670 hasLocation W23286536701 @default.

• next