Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328687652> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2328687652 endingPage "2667" @default.
- W2328687652 startingPage "2655" @default.
- W2328687652 abstract "The successful application of OctreoScan(®) ([(111)In-DTPA]octreotide) in the diagnosis of sst(2)-expressing neuroendocrine tumors (NETs), on one hand, and the manifestation of peptide receptor targets in a wide range of human cancers, on the other, have synergistically induced a booming emergence of numerous radiolabeled peptide (radiopeptide) probes for tumor diagnosis and therapy in man. Definition of molecular targets and their relation to neoplastic disease has preceded peptide-based radiopharmaceutical design and development. New criteria have been set to safeguard efficient localization of radionuclides on tumor-associated high affinity - low capacity peptide receptor systems. New technical and biological terms, such as specific activity or receptor affinity and internalization, have invaded the Radiopharmacy domain and have irrevocably altered our concept of radiopharmaceutical design. Nonetheless, (99m)Tc remains the gold standard of diagnostic nuclear medicine as a result of ideal nuclear characteristics, cost-effectiveness and wide availability in high purity and high specific activity by means of commercial (99)Mo/(99m)Tc-generators. The evolution of conventional (99m)Tc-perfusion agents into modern state-of-the-art molecular radiopharmaceuticals has been a challenge addressed by several researchers. The present review summarizes recent advances in the development of (99m)Tc-labeled peptides for in vivo targeting of neoplastic disease, and, in particular, those functionalized with acyclic tetraamines. Conclusions on their applicability in non-invasive diagnosis and staging of cancer patients are drawn." @default.
- W2328687652 created "2016-06-24" @default.
- W2328687652 creator A5029897786 @default.
- W2328687652 creator A5079838266 @default.
- W2328687652 date "2013-03-01" @default.
- W2328687652 modified "2023-10-03" @default.
- W2328687652 title "Tetraamine-Coupled Peptides and Resulting 99mTc-Radioligands: An Effective Route for Receptor-Targeted Diagnostic Imaging of Human Tumors" @default.
- W2328687652 doi "https://doi.org/10.2174/1568026611212230003" @default.
- W2328687652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23339761" @default.
- W2328687652 hasPublicationYear "2013" @default.
- W2328687652 type Work @default.
- W2328687652 sameAs 2328687652 @default.
- W2328687652 citedByCount "24" @default.
- W2328687652 countsByYear W23286876522013 @default.
- W2328687652 countsByYear W23286876522014 @default.
- W2328687652 countsByYear W23286876522015 @default.
- W2328687652 countsByYear W23286876522016 @default.
- W2328687652 countsByYear W23286876522017 @default.
- W2328687652 countsByYear W23286876522018 @default.
- W2328687652 countsByYear W23286876522019 @default.
- W2328687652 countsByYear W23286876522020 @default.
- W2328687652 countsByYear W23286876522021 @default.
- W2328687652 countsByYear W23286876522022 @default.
- W2328687652 crossrefType "journal-article" @default.
- W2328687652 hasAuthorship W2328687652A5029897786 @default.
- W2328687652 hasAuthorship W2328687652A5079838266 @default.
- W2328687652 hasConcept C121608353 @default.
- W2328687652 hasConcept C126322002 @default.
- W2328687652 hasConcept C136339569 @default.
- W2328687652 hasConcept C139770010 @default.
- W2328687652 hasConcept C142724271 @default.
- W2328687652 hasConcept C150903083 @default.
- W2328687652 hasConcept C170493617 @default.
- W2328687652 hasConcept C185592680 @default.
- W2328687652 hasConcept C207001950 @default.
- W2328687652 hasConcept C2775842073 @default.
- W2328687652 hasConcept C2776970183 @default.
- W2328687652 hasConcept C2779066768 @default.
- W2328687652 hasConcept C2779281246 @default.
- W2328687652 hasConcept C2984398910 @default.
- W2328687652 hasConcept C2989005 @default.
- W2328687652 hasConcept C2993559085 @default.
- W2328687652 hasConcept C3017732841 @default.
- W2328687652 hasConcept C502942594 @default.
- W2328687652 hasConcept C55493867 @default.
- W2328687652 hasConcept C70721500 @default.
- W2328687652 hasConcept C71924100 @default.
- W2328687652 hasConcept C86803240 @default.
- W2328687652 hasConceptScore W2328687652C121608353 @default.
- W2328687652 hasConceptScore W2328687652C126322002 @default.
- W2328687652 hasConceptScore W2328687652C136339569 @default.
- W2328687652 hasConceptScore W2328687652C139770010 @default.
- W2328687652 hasConceptScore W2328687652C142724271 @default.
- W2328687652 hasConceptScore W2328687652C150903083 @default.
- W2328687652 hasConceptScore W2328687652C170493617 @default.
- W2328687652 hasConceptScore W2328687652C185592680 @default.
- W2328687652 hasConceptScore W2328687652C207001950 @default.
- W2328687652 hasConceptScore W2328687652C2775842073 @default.
- W2328687652 hasConceptScore W2328687652C2776970183 @default.
- W2328687652 hasConceptScore W2328687652C2779066768 @default.
- W2328687652 hasConceptScore W2328687652C2779281246 @default.
- W2328687652 hasConceptScore W2328687652C2984398910 @default.
- W2328687652 hasConceptScore W2328687652C2989005 @default.
- W2328687652 hasConceptScore W2328687652C2993559085 @default.
- W2328687652 hasConceptScore W2328687652C3017732841 @default.
- W2328687652 hasConceptScore W2328687652C502942594 @default.
- W2328687652 hasConceptScore W2328687652C55493867 @default.
- W2328687652 hasConceptScore W2328687652C70721500 @default.
- W2328687652 hasConceptScore W2328687652C71924100 @default.
- W2328687652 hasConceptScore W2328687652C86803240 @default.
- W2328687652 hasIssue "23" @default.
- W2328687652 hasLocation W23286876521 @default.
- W2328687652 hasLocation W23286876522 @default.
- W2328687652 hasOpenAccess W2328687652 @default.
- W2328687652 hasPrimaryLocation W23286876521 @default.
- W2328687652 hasRelatedWork W1518474861 @default.
- W2328687652 hasRelatedWork W2013839190 @default.
- W2328687652 hasRelatedWork W2099478219 @default.
- W2328687652 hasRelatedWork W2108579980 @default.
- W2328687652 hasRelatedWork W2110914223 @default.
- W2328687652 hasRelatedWork W2140767160 @default.
- W2328687652 hasRelatedWork W2328687652 @default.
- W2328687652 hasRelatedWork W2580675833 @default.
- W2328687652 hasRelatedWork W4225011188 @default.
- W2328687652 hasRelatedWork W4309336361 @default.
- W2328687652 hasVolume "12" @default.
- W2328687652 isParatext "false" @default.
- W2328687652 isRetracted "false" @default.
- W2328687652 magId "2328687652" @default.
- W2328687652 workType "article" @default.