Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328703221> ?p ?o ?g. }
- W2328703221 endingPage "6715" @default.
- W2328703221 startingPage "6700" @default.
- W2328703221 abstract "A novel class of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. A homology model of MAPKAP-K2 was generated and used to guide the initial SAR studies and to rationalize the observed selectivity over CDK2. An X-ray crystal structure of a compound from the active series bound to crystalline MAPKAP-K2 confirmed the predicted binding mode. This has enabled the discovery of a series of pyrazolo[1,5-a]pyrimidine derivatives showing good in vitro cellular potency as anti-TNF-α agents and in vivo efficacy in a mouse model of endotoxin shock." @default.
- W2328703221 created "2016-06-24" @default.
- W2328703221 creator A5001139159 @default.
- W2328703221 creator A5008069513 @default.
- W2328703221 creator A5011927437 @default.
- W2328703221 creator A5016065865 @default.
- W2328703221 creator A5023295086 @default.
- W2328703221 creator A5028711596 @default.
- W2328703221 creator A5032729137 @default.
- W2328703221 creator A5034374187 @default.
- W2328703221 creator A5038451838 @default.
- W2328703221 creator A5041377005 @default.
- W2328703221 creator A5044044592 @default.
- W2328703221 creator A5045166362 @default.
- W2328703221 creator A5045510469 @default.
- W2328703221 creator A5046226558 @default.
- W2328703221 creator A5046743331 @default.
- W2328703221 creator A5047978370 @default.
- W2328703221 creator A5053326956 @default.
- W2328703221 creator A5061129514 @default.
- W2328703221 creator A5063321018 @default.
- W2328703221 creator A5063661814 @default.
- W2328703221 creator A5064899304 @default.
- W2328703221 creator A5067826587 @default.
- W2328703221 creator A5069624590 @default.
- W2328703221 creator A5074111659 @default.
- W2328703221 creator A5075460106 @default.
- W2328703221 creator A5077928665 @default.
- W2328703221 creator A5082316845 @default.
- W2328703221 creator A5083719662 @default.
- W2328703221 creator A5090246967 @default.
- W2328703221 date "2012-07-31" @default.
- W2328703221 modified "2023-10-01" @default.
- W2328703221 title "Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-<i>a</i>]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach" @default.
- W2328703221 cites W1498614151 @default.
- W2328703221 cites W1555014582 @default.
- W2328703221 cites W1575030178 @default.
- W2328703221 cites W1970081776 @default.
- W2328703221 cites W1972963324 @default.
- W2328703221 cites W1975974673 @default.
- W2328703221 cites W1977683934 @default.
- W2328703221 cites W1992999907 @default.
- W2328703221 cites W2005293659 @default.
- W2328703221 cites W2017040808 @default.
- W2328703221 cites W2032731042 @default.
- W2328703221 cites W2033320490 @default.
- W2328703221 cites W2037117792 @default.
- W2328703221 cites W2039077632 @default.
- W2328703221 cites W2039816703 @default.
- W2328703221 cites W2044959738 @default.
- W2328703221 cites W2047695218 @default.
- W2328703221 cites W2053304083 @default.
- W2328703221 cites W2053710312 @default.
- W2328703221 cites W2062340794 @default.
- W2328703221 cites W2065568989 @default.
- W2328703221 cites W2085988179 @default.
- W2328703221 cites W2091448951 @default.
- W2328703221 cites W2092382665 @default.
- W2328703221 cites W2095285037 @default.
- W2328703221 cites W2106591690 @default.
- W2328703221 cites W2118181515 @default.
- W2328703221 cites W2127551467 @default.
- W2328703221 cites W2135133228 @default.
- W2328703221 cites W2157068896 @default.
- W2328703221 cites W2161975618 @default.
- W2328703221 cites W2164304745 @default.
- W2328703221 cites W4242263464 @default.
- W2328703221 cites W4248324024 @default.
- W2328703221 cites W64396096 @default.
- W2328703221 cites W69602101 @default.
- W2328703221 doi "https://doi.org/10.1021/jm300411k" @default.
- W2328703221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22746295" @default.
- W2328703221 hasPublicationYear "2012" @default.
- W2328703221 type Work @default.
- W2328703221 sameAs 2328703221 @default.
- W2328703221 citedByCount "35" @default.
- W2328703221 countsByYear W23287032212013 @default.
- W2328703221 countsByYear W23287032212014 @default.
- W2328703221 countsByYear W23287032212015 @default.
- W2328703221 countsByYear W23287032212016 @default.
- W2328703221 countsByYear W23287032212017 @default.
- W2328703221 countsByYear W23287032212018 @default.
- W2328703221 countsByYear W23287032212019 @default.
- W2328703221 countsByYear W23287032212021 @default.
- W2328703221 countsByYear W23287032212022 @default.
- W2328703221 countsByYear W23287032212023 @default.
- W2328703221 crossrefType "journal-article" @default.
- W2328703221 hasAuthorship W2328703221A5001139159 @default.
- W2328703221 hasAuthorship W2328703221A5008069513 @default.
- W2328703221 hasAuthorship W2328703221A5011927437 @default.
- W2328703221 hasAuthorship W2328703221A5016065865 @default.
- W2328703221 hasAuthorship W2328703221A5023295086 @default.
- W2328703221 hasAuthorship W2328703221A5028711596 @default.
- W2328703221 hasAuthorship W2328703221A5032729137 @default.
- W2328703221 hasAuthorship W2328703221A5034374187 @default.
- W2328703221 hasAuthorship W2328703221A5038451838 @default.
- W2328703221 hasAuthorship W2328703221A5041377005 @default.
- W2328703221 hasAuthorship W2328703221A5044044592 @default.