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• W2328743370 abstract "Men with end-stage renal disease are frequently given androgen supplements to improve sexual function. Endogenous androgens contribute to hypertension and renal injury in various animal models. We hypothesized that testosterone supplements exacerbate hypertension and renal injury in rats with reduced renal mass (RRM). Rats subjected to surgical ablation of 80% of renal mass were given 8% NaCl diet for 6 weeks. Testosterone was administered in Silastic ® pellets throughout the study to groups of rats with intact or ablated kidneys. Arterial pressure was continuously monitored by telemetry. Renal injury was assessed by measurements of urinary protein and neutrophil gelatinase-associated lipocalin (NGAL) excretion. RRM developed hypertension on the high salt diet as compared with intact rats (154±12 vs 111±3mmHg). Testosterone supplementation did not alter the course of hypertension in RRM, nor increased blood pressure in Sham rats (156±12 vs 113±8mmHg, RRM vs Sham). Testosterone-supplemented RRM consistently excreted 20 to 30% more protein than untreated RRM. Urinary levels of NGAL, an index of tubulointerstitial injury, were also higher in RRM as compared to intact rats and were further augmented by testosterone supplements. Our data indicate that testosterone supplements worsen renal injury in a model of chronic hypertensive renal disease without affecting blood pressure. Rezumat Terapia de suplimentare cu androgeni este frecvent utilizata la barbații care sufera de insuficiența renala, cu scopul de a ameliora funcția sexuala. Androgenii endogeni contribuie la hipertensiune și afectarea renala in diferite modele experimentale. Am formulat ipoteza conform careia suplimentele cu testosteron exacerbeaza hipertensiunea și boala renala la șobolani cu masa renala redusa (RRM). Șobolanilor supuși ablației chirurgicale a 80% din masa renala li s-a administrat apoi o dieta cu 8% NaCl timp de 6 saptamâni. Testosteronul a fost administrat in pelete de Silastic ® pe toata durata studiului grupurilor de șobolani cu ablație renala sau rinichi intacți. Tensiunea arteriala a fost monitorizata continuu prin telemetrie. Afectarea renala a fost determinata prin masurarea excreției urinare de proteine și a lipocalinei asociate gelatinazei neutrofilice (NGAL). Grupul RRM a dezvoltat hipertensiune arteriala in timul dietei hipersodate, in comparație cu șobolanii cu rinichi intacți (154±12 fața de 111±3mmHg). Suplimentele de testosteron nu au modificat apariția hipertensiunii la RRM tratați și nici nu au crescut tensiunea" @default.
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• W2328743370 date "2014-01-01" @default.
• W2328743370 modified "2023-09-27" @default.
• W2328743370 title "TESTOSTERONE SUPPLEMENTS ACCELERATE PROGRESSION OF KIDNEY INJURY IN A RAT MODEL OF REDUCED RENAL MASS" @default.
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