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- W2328745153 abstract "An increase in pulsatile release of luteinizing hormone-releasing hormone (LHRH) is essential for the onset of puberty. The pubertal increase in LHRH release triggers an elevation of gonadotropin secretion which, in turn, controls steroidogenesis and gametogenesis, resulting in puberty. Although LHRH agonists have been used in humans to treat disorders associated with puberty, the mechanism of the increase in LHRH release during puberty is still unclear. This review describes the possible mechanism involved in the pubertal increase in pulsatile LHRH release in primates. That is, the increase in LHRH release is triggered by the reduction of inhibitory γ-aminobutyric acid (GABA) input and a subsequent increase in excitatory glutamatergic input to the LHRH neurosecretory system in the hypothalamus. Other stimulatory signals, such as those from norepinephrine (NE) and neuropeptide Y (NPY) neurons, appear to further contribute to this event." @default.
- W2328745153 created "2016-06-24" @default.
- W2328745153 creator A5061445584 @default.
- W2328745153 date "1999-02-01" @default.
- W2328745153 modified "2023-10-16" @default.
- W2328745153 title "Hypothalamic mechanism of the onset of puberty" @default.
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- W2328745153 doi "https://doi.org/10.1097/00060793-199902000-00008" @default.
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