FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328761257> ?p ?o ?g. }

• W2328761257 endingPage "3111" @default.
• W2328761257 startingPage "3103" @default.
• W2328761257 abstract "Activated macrophages play a significant role in initiation and progression of inflammatory diseases and may serve as the basis for the development of targeted diagnostic methods for imaging sites of inflammation. Folate receptor beta (FR-β) is differentially expressed on activated macrophages associated with inflammatory disease states yet is absent in either quiescent or resting macrophages. Because folate binds with high affinity to FR-β, development of folate directed imaging agents has proceeded rapidly in the past decade. However, reports of PET based imaging agents for use in inflammatory conditions remain limited. To investigate whether FR-β expressing macrophages could be exploited for PET based inflammatory imaging, two separate folate-targeted PET imaging agents were developed, 4-[(18)F]-fluorophenylfolate and [(68)Ga]-DOTA-folate, and their ability to target activated macrophages were examined in a rodent inflammatory paw model. We further compared inflamed tissue uptake with 2-[(18)F]fluoro-2-deoxy-d-glucose ([(18)F]-FDG). microPET analysis demonstrated that both folate-targeted PET tracers had higher uptake in the inflamed paw compared to the control paw. When these radiotracers were compared to [(18)F]-FDG, both folate PET tracers had a higher signal-to-noise ratio (SNR) than [(18)F]-FDG, suggesting that folate tracers may be superior to [(18)F]-FDG in detecting diseases with an inflammatory component. Moreover, both folate-PET imaging agents also bind to FR-α which is overexpressed on multiple human cancers. Therefore, these folate derived PET tracers may also find use for localizing and staging FR(+) cancers, monitoring response to therapy, and for selecting patients for tandem folate-targeted therapies." @default.
• W2328761257 created "2016-06-24" @default.
• W2328761257 creator A5001482204 @default.
• W2328761257 creator A5002553193 @default.
• W2328761257 creator A5003633447 @default.
• W2328761257 creator A5009068250 @default.
• W2328761257 creator A5042316902 @default.
• W2328761257 creator A5055944239 @default.
• W2328761257 creator A5061226497 @default.
• W2328761257 creator A5071989328 @default.
• W2328761257 creator A5078460867 @default.
• W2328761257 creator A5083893913 @default.
• W2328761257 creator A5089609044 @default.
• W2328761257 date "2013-07-24" @default.
• W2328761257 modified "2023-09-27" @default.
• W2328761257 title "Comparative Analysis of Folate Derived PET Imaging Agents with [18F]-2-Fluoro-2-deoxy-d-glucose Using a Rodent Inflammatory Paw Model" @default.
• W2328761257 cites W108344161 @default.
• W2328761257 cites W162995140 @default.
• W2328761257 cites W1970923789 @default.
• W2328761257 cites W1971245971 @default.
• W2328761257 cites W1972849029 @default.
• W2328761257 cites W1973189779 @default.
• W2328761257 cites W1976063457 @default.
• W2328761257 cites W1976971356 @default.
• W2328761257 cites W1977109672 @default.
• W2328761257 cites W1977866186 @default.
• W2328761257 cites W1993388378 @default.
• W2328761257 cites W2000605631 @default.
• W2328761257 cites W2015766239 @default.
• W2328761257 cites W2021756557 @default.
• W2328761257 cites W2033835940 @default.
• W2328761257 cites W2038689279 @default.
• W2328761257 cites W2042493999 @default.
• W2328761257 cites W2054759893 @default.
• W2328761257 cites W2056306723 @default.
• W2328761257 cites W2060459188 @default.
• W2328761257 cites W2063024908 @default.
• W2328761257 cites W2072294808 @default.
• W2328761257 cites W2076109390 @default.
• W2328761257 cites W2077450760 @default.
• W2328761257 cites W2079082252 @default.
• W2328761257 cites W2083628264 @default.
• W2328761257 cites W2102695123 @default.
• W2328761257 cites W2116725368 @default.
• W2328761257 cites W2117868980 @default.
• W2328761257 cites W2118286464 @default.
• W2328761257 cites W2119566474 @default.
• W2328761257 cites W2123333870 @default.
• W2328761257 cites W2133786616 @default.
• W2328761257 cites W2136157736 @default.
• W2328761257 cites W2140403679 @default.
• W2328761257 cites W2145697808 @default.
• W2328761257 cites W2148317617 @default.
• W2328761257 cites W2150451572 @default.
• W2328761257 cites W2241430554 @default.
• W2328761257 cites W2340746171 @default.
• W2328761257 cites W4213261511 @default.
• W2328761257 cites W2083839337 @default.
• W2328761257 doi "https://doi.org/10.1021/mp4001684" @default.
• W2328761257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23819524" @default.
• W2328761257 hasPublicationYear "2013" @default.
• W2328761257 type Work @default.
• W2328761257 sameAs 2328761257 @default.
• W2328761257 citedByCount "25" @default.
• W2328761257 countsByYear W23287612572014 @default.
• W2328761257 countsByYear W23287612572015 @default.
• W2328761257 countsByYear W23287612572016 @default.
• W2328761257 countsByYear W23287612572017 @default.
• W2328761257 countsByYear W23287612572018 @default.
• W2328761257 countsByYear W23287612572020 @default.
• W2328761257 countsByYear W23287612572021 @default.
• W2328761257 countsByYear W23287612572022 @default.
• W2328761257 countsByYear W23287612572023 @default.
• W2328761257 crossrefType "journal-article" @default.
• W2328761257 hasAuthorship W2328761257A5001482204 @default.
• W2328761257 hasAuthorship W2328761257A5002553193 @default.
• W2328761257 hasAuthorship W2328761257A5003633447 @default.
• W2328761257 hasAuthorship W2328761257A5009068250 @default.
• W2328761257 hasAuthorship W2328761257A5042316902 @default.
• W2328761257 hasAuthorship W2328761257A5055944239 @default.
• W2328761257 hasAuthorship W2328761257A5061226497 @default.
• W2328761257 hasAuthorship W2328761257A5071989328 @default.
• W2328761257 hasAuthorship W2328761257A5078460867 @default.
• W2328761257 hasAuthorship W2328761257A5083893913 @default.
• W2328761257 hasAuthorship W2328761257A5089609044 @default.
• W2328761257 hasConcept C121608353 @default.
• W2328761257 hasConcept C126322002 @default.
• W2328761257 hasConcept C136339569 @default.
• W2328761257 hasConcept C150903083 @default.
• W2328761257 hasConcept C185592680 @default.
• W2328761257 hasConcept C203014093 @default.
• W2328761257 hasConcept C207001950 @default.
• W2328761257 hasConcept C2775842073 @default.
• W2328761257 hasConcept C2776914184 @default.
• W2328761257 hasConcept C2778172261 @default.
• W2328761257 hasConcept C2780306303 @default.
• W2328761257 hasConcept C2989005 @default.
• W2328761257 hasConcept C3017724952 @default.

• next