FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328778894> ?p ?o ?g. }

• W2328778894 endingPage "18789" @default.
• W2328778894 startingPage "18786" @default.
• W2328778894 abstract "Long human telomeric fragments can form stable, higher-order G-quadruplex structures, recently identified in human cells, which are potential drug targets. However, there are very few examples of ligand binding to higher-order G-quadruplexes, and all the reported ligands are proposed to bind at the cleft between two G-quadruplexes. Here we report that zinc-finger-like chiral supramolecular complexes prefer binding to higher-order G-quadruplexes over a single G-quadruplex, with ∼200-fold higher selectivity. To our knowledge, this is the first example of a ligand that can distinguish higher-order G-quadruplexes from a single G-quadruplex with such high selectivity. Further studies indicate that the nanosized chiral complex would bind to two well-matched G-quadruplex units, instead of binding at the cleft between the two G-quadruplexes. These results provide new insights into the targeting of higher-order G-quadruplex ligands. Our work illustrates that dimeric G-quadruplex units can be ligand-preferred binding sites." @default.
• W2328778894 created "2016-06-24" @default.
• W2328778894 creator A5027459729 @default.
• W2328778894 creator A5065069789 @default.
• W2328778894 creator A5068819818 @default.
• W2328778894 creator A5077495486 @default.
• W2328778894 creator A5090202020 @default.
• W2328778894 date "2013-12-02" @default.
• W2328778894 modified "2023-10-02" @default.
• W2328778894 title "Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site" @default.
• W2328778894 cites W1966501382 @default.
• W2328778894 cites W1974800636 @default.
• W2328778894 cites W1981888951 @default.
• W2328778894 cites W1984601916 @default.
• W2328778894 cites W1990074185 @default.
• W2328778894 cites W1991797965 @default.
• W2328778894 cites W2005190101 @default.
• W2328778894 cites W2006397579 @default.
• W2328778894 cites W2007812774 @default.
• W2328778894 cites W2008120871 @default.
• W2328778894 cites W2008182786 @default.
• W2328778894 cites W2010999047 @default.
• W2328778894 cites W2016931143 @default.
• W2328778894 cites W2021123988 @default.
• W2328778894 cites W2021191052 @default.
• W2328778894 cites W2028397348 @default.
• W2328778894 cites W2035485234 @default.
• W2328778894 cites W2038304204 @default.
• W2328778894 cites W2039241171 @default.
• W2328778894 cites W2039835294 @default.
• W2328778894 cites W2041954922 @default.
• W2328778894 cites W2044480512 @default.
• W2328778894 cites W2044760989 @default.
• W2328778894 cites W2047873173 @default.
• W2328778894 cites W2048748100 @default.
• W2328778894 cites W2049059550 @default.
• W2328778894 cites W2056321432 @default.
• W2328778894 cites W2056826169 @default.
• W2328778894 cites W2058302347 @default.
• W2328778894 cites W2059306569 @default.
• W2328778894 cites W2062724831 @default.
• W2328778894 cites W2070826483 @default.
• W2328778894 cites W2071638222 @default.
• W2328778894 cites W2072258154 @default.
• W2328778894 cites W2074071832 @default.
• W2328778894 cites W2078843953 @default.
• W2328778894 cites W2079954805 @default.
• W2328778894 cites W2081781483 @default.
• W2328778894 cites W2083703501 @default.
• W2328778894 cites W2087568613 @default.
• W2328778894 cites W2092058466 @default.
• W2328778894 cites W2113202602 @default.
• W2328778894 cites W2114769365 @default.
• W2328778894 cites W2115127516 @default.
• W2328778894 cites W2117413664 @default.
• W2328778894 cites W2119762097 @default.
• W2328778894 cites W2120168398 @default.
• W2328778894 cites W2125469057 @default.
• W2328778894 cites W2126860897 @default.
• W2328778894 cites W2130272241 @default.
• W2328778894 cites W2132798822 @default.
• W2328778894 cites W2139032214 @default.
• W2328778894 cites W2147019065 @default.
• W2328778894 cites W2155773930 @default.
• W2328778894 cites W2163661389 @default.
• W2328778894 cites W2165212123 @default.
• W2328778894 cites W2166630132 @default.
• W2328778894 cites W2172060739 @default.
• W2328778894 cites W2282861001 @default.
• W2328778894 cites W2314764775 @default.
• W2328778894 doi "https://doi.org/10.1021/ja410723r" @default.
• W2328778894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24266854" @default.
• W2328778894 hasPublicationYear "2013" @default.
• W2328778894 type Work @default.
• W2328778894 sameAs 2328778894 @default.
• W2328778894 citedByCount "121" @default.
• W2328778894 countsByYear W23287788942014 @default.
• W2328778894 countsByYear W23287788942015 @default.
• W2328778894 countsByYear W23287788942016 @default.
• W2328778894 countsByYear W23287788942017 @default.
• W2328778894 countsByYear W23287788942018 @default.
• W2328778894 countsByYear W23287788942019 @default.
• W2328778894 countsByYear W23287788942020 @default.
• W2328778894 countsByYear W23287788942021 @default.
• W2328778894 countsByYear W23287788942022 @default.
• W2328778894 countsByYear W23287788942023 @default.
• W2328778894 crossrefType "journal-article" @default.
• W2328778894 hasAuthorship W2328778894A5027459729 @default.
• W2328778894 hasAuthorship W2328778894A5065069789 @default.
• W2328778894 hasAuthorship W2328778894A5068819818 @default.
• W2328778894 hasAuthorship W2328778894A5077495486 @default.
• W2328778894 hasAuthorship W2328778894A5090202020 @default.
• W2328778894 hasConcept C107824862 @default.
• W2328778894 hasConcept C115624301 @default.
• W2328778894 hasConcept C116569031 @default.
• W2328778894 hasConcept C118792377 @default.
• W2328778894 hasConcept C12554922 @default.
• W2328778894 hasConcept C161790260 @default.

• next