FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328851905> ?p ?o ?g. }

• W2328851905 abstract "To establish whether activation of adenosine type-3 receptors (A3Rs) and inhibition of interleukin-1β-induced inflammation is beneficial in combination with antibiotic therapy to increase survival of mice challenged with anthrax spores.DBA/2 mice were challenged with Bacillus anthracis spores of the toxigenic Sterne strain 43F2. Survival of animals was monitored for 15 d. Ciprofloxacin treatment (50 mg/kg, once daily, intraperitoneally) was initiated at day +1 simultaneously with the administration of inhibitors, and continued for 10 d. Two doses (2.5 mg/kg and 12.5 mg/kg) of acetyl-tyrosyl-valyl-alanyl-aspartyl-chloromethylketone (YVAD) and three doses (0.05, 0.15 and 0.3 mg/kg) of 1-[2-Chloro-6-[[(3-iodophenyl) methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D- ribofuranuronamide (Cl-IB-MECA) were tested. Animals received YVAD on days 1-4, and Cl-IB-MECA on days 1-10 once daily, subcutaneously. Human lung epithelial cells in culture were challenged with spores or edema toxin and the effects of IB-MECA on phosphorylation of AKT and generation of cAMP were tested.We showed that the outcome of antibiotic treatment in a murine anthrax model could be substantially improved by co-administration of the caspase-1/4 inhibitor YVAD and the A3R agonist Cl-IB-MECA. Combination treatment with these substances and ciprofloxacin resulted in up to 90% synergistic protection. All untreated mice died, and antibiotic alone protected only 30% of animals. We conclude that both substances target the aberrant host signaling that underpins anthrax mortality.Our findings suggest new possibilities for combination therapy of anthrax with antibiotics, A3R agonists and caspase-1 inhibitors." @default.
• W2328851905 created "2016-06-24" @default.
• W2328851905 creator A5016700147 @default.
• W2328851905 creator A5046801159 @default.
• W2328851905 creator A5067049222 @default.
• W2328851905 creator A5078625340 @default.
• W2328851905 date "2011-01-01" @default.
• W2328851905 modified "2023-09-24" @default.
• W2328851905 title "Targeting the inflammasome and adenosine type-3 receptors improves outcome of antibiotic therapy in murine anthrax" @default.
• W2328851905 cites W1568017692 @default.
• W2328851905 cites W1968411474 @default.
• W2328851905 cites W1970579406 @default.
• W2328851905 cites W1980729145 @default.
• W2328851905 cites W1982900087 @default.
• W2328851905 cites W1994663540 @default.
• W2328851905 cites W1996979039 @default.
• W2328851905 cites W2001095885 @default.
• W2328851905 cites W2005654018 @default.
• W2328851905 cites W2007934886 @default.
• W2328851905 cites W2028553476 @default.
• W2328851905 cites W2029962300 @default.
• W2328851905 cites W2034599479 @default.
• W2328851905 cites W2042168393 @default.
• W2328851905 cites W2059275861 @default.
• W2328851905 cites W2061136308 @default.
• W2328851905 cites W2061901991 @default.
• W2328851905 cites W2063701534 @default.
• W2328851905 cites W2068299732 @default.
• W2328851905 cites W2074959423 @default.
• W2328851905 cites W2082218499 @default.
• W2328851905 cites W2087032216 @default.
• W2328851905 cites W2103828083 @default.
• W2328851905 cites W2113136182 @default.
• W2328851905 cites W2125784517 @default.
• W2328851905 cites W2129435138 @default.
• W2328851905 cites W2137360409 @default.
• W2328851905 cites W2144676258 @default.
• W2328851905 cites W2147114673 @default.
• W2328851905 cites W2157932674 @default.
• W2328851905 doi "https://doi.org/10.4331/wjbc.v2.i5.98" @default.
• W2328851905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3110900" @default.
• W2328851905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21666812" @default.
• W2328851905 hasPublicationYear "2011" @default.
• W2328851905 type Work @default.
• W2328851905 sameAs 2328851905 @default.
• W2328851905 citedByCount "3" @default.
• W2328851905 countsByYear W23288519052014 @default.
• W2328851905 countsByYear W23288519052015 @default.
• W2328851905 crossrefType "journal-article" @default.
• W2328851905 hasAuthorship W2328851905A5016700147 @default.
• W2328851905 hasAuthorship W2328851905A5046801159 @default.
• W2328851905 hasAuthorship W2328851905A5067049222 @default.
• W2328851905 hasAuthorship W2328851905A5078625340 @default.
• W2328851905 hasBestOaLocation W23288519051 @default.
• W2328851905 hasConcept C126322002 @default.
• W2328851905 hasConcept C170493617 @default.
• W2328851905 hasConcept C177713679 @default.
• W2328851905 hasConcept C203014093 @default.
• W2328851905 hasConcept C2776991684 @default.
• W2328851905 hasConcept C2777209026 @default.
• W2328851905 hasConcept C2993328841 @default.
• W2328851905 hasConcept C501593827 @default.
• W2328851905 hasConcept C71924100 @default.
• W2328851905 hasConcept C86803240 @default.
• W2328851905 hasConcept C89423630 @default.
• W2328851905 hasConcept C98274493 @default.
• W2328851905 hasConceptScore W2328851905C126322002 @default.
• W2328851905 hasConceptScore W2328851905C170493617 @default.
• W2328851905 hasConceptScore W2328851905C177713679 @default.
• W2328851905 hasConceptScore W2328851905C203014093 @default.
• W2328851905 hasConceptScore W2328851905C2776991684 @default.
• W2328851905 hasConceptScore W2328851905C2777209026 @default.
• W2328851905 hasConceptScore W2328851905C2993328841 @default.
• W2328851905 hasConceptScore W2328851905C501593827 @default.
• W2328851905 hasConceptScore W2328851905C71924100 @default.
• W2328851905 hasConceptScore W2328851905C86803240 @default.
• W2328851905 hasConceptScore W2328851905C89423630 @default.
• W2328851905 hasConceptScore W2328851905C98274493 @default.
• W2328851905 hasLocation W23288519051 @default.
• W2328851905 hasLocation W23288519052 @default.
• W2328851905 hasLocation W23288519053 @default.
• W2328851905 hasLocation W23288519054 @default.
• W2328851905 hasOpenAccess W2328851905 @default.
• W2328851905 hasPrimaryLocation W23288519051 @default.
• W2328851905 hasRelatedWork W1412498810 @default.
• W2328851905 hasRelatedWork W1505563617 @default.
• W2328851905 hasRelatedWork W2033426620 @default.
• W2328851905 hasRelatedWork W2044959914 @default.
• W2328851905 hasRelatedWork W2074569502 @default.
• W2328851905 hasRelatedWork W2328030460 @default.
• W2328851905 hasRelatedWork W2412771361 @default.
• W2328851905 hasRelatedWork W2415438355 @default.
• W2328851905 hasRelatedWork W2801332391 @default.
• W2328851905 hasRelatedWork W2888464037 @default.
• W2328851905 hasRelatedWork W2997745200 @default.
• W2328851905 hasRelatedWork W3009996320 @default.
• W2328851905 hasRelatedWork W3016685483 @default.
• W2328851905 hasRelatedWork W3088309526 @default.
• W2328851905 hasRelatedWork W3096783078 @default.
• W2328851905 hasRelatedWork W3105266821 @default.

• next