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• W2328854561 endingPage "11989" @default.
• W2328854561 startingPage "11985" @default.
• W2328854561 abstract "For over 50 years the G-quartet has been a defining self-assembled structure in biology and non-covalent synthesis. It is shown here for the first time that the G-quartet is isolatable in water in the absence of stabilizing G-quartet stacking or cations through the construction of a phosphate-linked template-assembled synthetic G-quartet. Synthetic design has facilitated preservation of the guanine base, ribose sugar, and phosphate components with correct linkage chemistry relative to G-quadruplex DNA. Thus, a minimal synthetic model of G-quadruplex DNA, as in that associated with human gene promoter or telomere regions, is represented by this system. An application as a probe for interactions between G-quadruplex DNA and potential anticancer therapeutical binding ligands is demonstrated. Binding constants of 10(5)-10(7) M(-1) magnitude and 1:1 stoichiometries for TMPyP4, piper, and azatrux ligands were determined, whereas perturbations in BSU1051 and BRACO19 ligand signal were not observed. These data suggest a unique test for critical end-stacking interactions at the exclusion of intercalative or looping interactions for G-quadruplex binding ligands." @default.
• W2328854561 created "2016-06-24" @default.
• W2328854561 creator A5030777163 @default.
• W2328854561 creator A5081454326 @default.
• W2328854561 creator A5090815103 @default.
• W2328854561 date "2013-08-01" @default.
• W2328854561 modified "2023-09-23" @default.
• W2328854561 title "Synthesis of a Single G-Quartet Platform in Water" @default.
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• W2328854561 doi "https://doi.org/10.1021/ja405100z" @default.
• W2328854561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23859130" @default.
• W2328854561 hasPublicationYear "2013" @default.
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