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- W2328879923 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCBasal cell carcinomas, the most common of human cancers, differ from many other cancers not only in their frequency but also in the great rarity with which they metastasize and their routinely high cure rate following surgery. Because all BCCs are driven by mutational activation of the hedgehog signaling pathway in the tumor cells, small molecule hedgehog inhibitors are a “natural” approach. Indeed, not only the rare metastatic and locally advanced BCCs but also the high number of smaller individually less aggressive BCCs in patients with the Gorlin syndrome respond extremely well to small molecule Hedgehog inhibitors. This illustrates that interfering with critical pathways not only can treat existing tumors but also can prevent even the development of new tumors.Citation Format: Ervin H. Epstein. Inhibition of Hedgehog signaling for prevention and treatment of basal cell carcinomas. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr SY02-04. doi:10.1158/1538-7445.AM2013-SY02-04" @default.
- W2328879923 created "2016-06-24" @default.
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- W2328879923 date "2013-04-15" @default.
- W2328879923 modified "2023-09-27" @default.
- W2328879923 title "Abstract SY02-04: Inhibition of Hedgehog signaling for prevention and treatment of basal cell carcinomas." @default.
- W2328879923 doi "https://doi.org/10.1158/1538-7445.am2013-sy02-04" @default.
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