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• W2328903599 endingPage "e1151591" @default.
• W2328903599 startingPage "e1151591" @default.
• W2328903599 abstract "Histamine receptor 2 (H2) antagonists are widely used clinically for the control of gastrointestinal symptoms, but also impact immune function. They have been reported to reduce tumor growth in established colon and lung cancer models. Histamine has also been reported to modify populations of myeloid-derived suppressor cells (MDSCs). We have examined the impact of the widely used H2 antagonist ranitidine, on both myeloid cell populations and tumor development and spread, in three distinct models of breast cancer that highlight different stages of cancer progression. Oral ranitidine treatment significantly decreased the monocytic MDSC population in the spleen and bone marrow both alone and in the context of an orthotopic breast tumor model. H2 antagonists ranitidine and famotidine, but not H1 or H4 antagonists, significantly inhibited lung metastasis in the 4T1 model. In the E0771 model, ranitidine decreased primary tumor growth while omeprazole treatment had no impact on tumor development. Gemcitabine treatment prevented the tumor growth inhibition associated with ranitidine treatment. In keeping with ranitidine-induced changes in myeloid cell populations in non-tumor-bearing mice, ranitidine also delayed the onset of spontaneous tumor development, and decreased the number of tumors that developed in LKB1−/−/NIC mice. These results indicate that ranitidine alters monocyte populations associated with MDSC activity, and subsequently impacts breast tumor development and outcome. Ranitidine has potential as an adjuvant therapy or preventative agent in breast cancer and provides a novel and safe approach to the long-term reduction of tumor-associated immune suppression." @default.
• W2328903599 created "2016-06-24" @default.
• W2328903599 creator A5002268144 @default.
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• W2328903599 date "2016-03-10" @default.
• W2328903599 modified "2023-10-18" @default.
• W2328903599 title "Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice" @default.
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• W2328903599 doi "https://doi.org/10.1080/2162402x.2016.1151591" @default.
• W2328903599 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5006904" @default.
• W2328903599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27622015" @default.
• W2328903599 hasPublicationYear "2016" @default.
• W2328903599 type Work @default.

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