Matches in SemOpenAlex for { <https://semopenalex.org/work/W2328904629> ?p ?o ?g. }
- W2328904629 endingPage "1314" @default.
- W2328904629 startingPage "1307" @default.
- W2328904629 abstract "Vectors based on Semliki Forest virus (SFV) have been widely used in vitro and in vivo to express heterologous genes in animal cells. In particular, the ability of recombinant SFV (rSFV) to elicit specific, protective immune responses in animal models suggests that rSFV may be used as a vaccine vehicle. In this study, we examined the distribution of rSFV in vivo by immunohistochemistry and RT-PCR after intravenous, intramuscular and subcutaneous injection of rSFV particles and related this to the degree of cytotoxic T lymphocyte (CTL) responses and frequency of specific T cells detected by MHC-I tetramers. We found that after i.v. injection, rSFV-RNA was distributed to a variety of different tissues, whereas it was confined locally after i.m. and s.c. injections. The persistence of the rSFV vector was transient, and no viral RNA could be detected 10 days after inoculation. All tested routes of immunization generated significant levels of antigen-specific CTL responses and increased numbers of specific CD8+ T cells, as detected by tetramer binding. The distribution of antigen-specific CTLs correlated with the in vivo distribution pattern of rSFV, with a highest frequency in the spleen or local lymph node, depending on the injection route." @default.
- W2328904629 created "2016-06-24" @default.
- W2328904629 creator A5000229478 @default.
- W2328904629 creator A5020078440 @default.
- W2328904629 creator A5037534938 @default.
- W2328904629 creator A5049241081 @default.
- W2328904629 creator A5057077024 @default.
- W2328904629 creator A5066029443 @default.
- W2328904629 date "2001-09-01" @default.
- W2328904629 modified "2023-10-10" @default.
- W2328904629 title "Recombinant Semliki Forest virus vaccine vectors: the route of injection determines the localization of vector RNA and subsequent T cell response" @default.
- W2328904629 cites W1548951258 @default.
- W2328904629 cites W1561591381 @default.
- W2328904629 cites W1855484651 @default.
- W2328904629 cites W1966055810 @default.
- W2328904629 cites W1970136118 @default.
- W2328904629 cites W1998667730 @default.
- W2328904629 cites W2011275029 @default.
- W2328904629 cites W2014495927 @default.
- W2328904629 cites W2017760748 @default.
- W2328904629 cites W2019140357 @default.
- W2328904629 cites W2053111306 @default.
- W2328904629 cites W2054647904 @default.
- W2328904629 cites W2055047899 @default.
- W2328904629 cites W2071689629 @default.
- W2328904629 cites W2072139616 @default.
- W2328904629 cites W2083689618 @default.
- W2328904629 cites W2088978732 @default.
- W2328904629 cites W2090821486 @default.
- W2328904629 cites W2098174187 @default.
- W2328904629 cites W2099371098 @default.
- W2328904629 cites W2100201151 @default.
- W2328904629 cites W2108028766 @default.
- W2328904629 cites W2114843456 @default.
- W2328904629 cites W2120233943 @default.
- W2328904629 cites W2139871947 @default.
- W2328904629 cites W2140485581 @default.
- W2328904629 cites W2145824031 @default.
- W2328904629 cites W2159693720 @default.
- W2328904629 cites W2314102978 @default.
- W2328904629 cites W2319108291 @default.
- W2328904629 cites W2322148397 @default.
- W2328904629 cites W2323496042 @default.
- W2328904629 cites W4236539492 @default.
- W2328904629 doi "https://doi.org/10.1038/sj.gt.3301501" @default.
- W2328904629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11571567" @default.
- W2328904629 hasPublicationYear "2001" @default.
- W2328904629 type Work @default.
- W2328904629 sameAs 2328904629 @default.
- W2328904629 citedByCount "25" @default.
- W2328904629 countsByYear W23289046292012 @default.
- W2328904629 countsByYear W23289046292022 @default.
- W2328904629 countsByYear W23289046292023 @default.
- W2328904629 crossrefType "journal-article" @default.
- W2328904629 hasAuthorship W2328904629A5000229478 @default.
- W2328904629 hasAuthorship W2328904629A5020078440 @default.
- W2328904629 hasAuthorship W2328904629A5037534938 @default.
- W2328904629 hasAuthorship W2328904629A5049241081 @default.
- W2328904629 hasAuthorship W2328904629A5057077024 @default.
- W2328904629 hasAuthorship W2328904629A5066029443 @default.
- W2328904629 hasBestOaLocation W23289046291 @default.
- W2328904629 hasConcept C104317684 @default.
- W2328904629 hasConcept C147483822 @default.
- W2328904629 hasConcept C147969180 @default.
- W2328904629 hasConcept C150903083 @default.
- W2328904629 hasConcept C153911025 @default.
- W2328904629 hasConcept C154317977 @default.
- W2328904629 hasConcept C159047783 @default.
- W2328904629 hasConcept C159654299 @default.
- W2328904629 hasConcept C167672396 @default.
- W2328904629 hasConcept C202751555 @default.
- W2328904629 hasConcept C203014093 @default.
- W2328904629 hasConcept C207001950 @default.
- W2328904629 hasConcept C2522874641 @default.
- W2328904629 hasConcept C2777474056 @default.
- W2328904629 hasConcept C2779909307 @default.
- W2328904629 hasConcept C2780868878 @default.
- W2328904629 hasConcept C2780963514 @default.
- W2328904629 hasConcept C39060996 @default.
- W2328904629 hasConcept C40767141 @default.
- W2328904629 hasConcept C542903549 @default.
- W2328904629 hasConcept C55493867 @default.
- W2328904629 hasConcept C67705224 @default.
- W2328904629 hasConcept C86803240 @default.
- W2328904629 hasConcept C8891405 @default.
- W2328904629 hasConceptScore W2328904629C104317684 @default.
- W2328904629 hasConceptScore W2328904629C147483822 @default.
- W2328904629 hasConceptScore W2328904629C147969180 @default.
- W2328904629 hasConceptScore W2328904629C150903083 @default.
- W2328904629 hasConceptScore W2328904629C153911025 @default.
- W2328904629 hasConceptScore W2328904629C154317977 @default.
- W2328904629 hasConceptScore W2328904629C159047783 @default.
- W2328904629 hasConceptScore W2328904629C159654299 @default.
- W2328904629 hasConceptScore W2328904629C167672396 @default.
- W2328904629 hasConceptScore W2328904629C202751555 @default.
- W2328904629 hasConceptScore W2328904629C203014093 @default.
- W2328904629 hasConceptScore W2328904629C207001950 @default.
- W2328904629 hasConceptScore W2328904629C2522874641 @default.