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- W2328930091 abstract "A new composite bioceramic consisting of calcium aluminum oxide (CaAlO) and hydroxyapatite (HA) was functionalized with the synthetic antimicrobial peptide Inverso-CysHHC10. CaAlO is a bioceramic that can be mold cast easily and quickly at room temperature. Improved functionality was previously achieved through surface reactions. Here, composites containing 0–5% HA (by mass) were prepared and the elastic modulus and modulus of rupture were mechanically similar to non-load bearing bone. The addition of hydroxyapatite resulted in increased osteoblast attachment (> 180%) and proliferation (> 140%) on all composites compared to 100% CaAlO. Antimicrobial peptide (AMP) immobilization was achieved using an interfacial alkene-thiol click reaction. The linked AMP persisted on the composite (> 99.6% after 24 h) and retained its activity against Escherichia coli based on N-phenylnaphthylamine uptake and bacterial turbidity tests. Overall, this simple scaffold system improves osteoblast activity and reduces bacterial activity." @default.
- W2328930091 created "2016-06-24" @default.
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- W2328930091 date "2016-08-01" @default.
- W2328930091 modified "2023-10-14" @default.
- W2328930091 title "Reducing Escherichia coli growth on a composite biomaterial by a surface immobilized antimicrobial peptide" @default.
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- W2328930091 doi "https://doi.org/10.1016/j.msec.2016.04.021" @default.
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