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• W2328960066 abstract "Mammalian chromosome ends are protected by nucleoprotein structures called telomeres. Telomeres ensure genome stability by preventing chromosome termini from being recognized as DNA damage. Telomere length homeostasis is inevitable for telomere maintenance because critical shortening or over-lengthening of telomeres may lead to DNA damage response or delay in DNA replication, and hence genome instability. Due to their repetitive DNA sequence, unique architecture, bound shelterin proteins, and high propensity to form alternate/secondary DNA structures, telomeres are like common fragile sites and pose an inherent challenge to the progression of DNA replication, repair, and recombination apparatus. It is conceivable that longer the telomeres are, greater is the severity of such challenges. Recent studies have linked excessively long telomeres with increased tumorigenesis. Here we discuss telomere abnormalities in a rare recessive chromosomal instability disorder called Fanconi Anemia and the role of the Fanconi Anemia pathway in telomere biology. Reports suggest that Fanconi Anemia proteins play a role in maintaining long telomeres, including processing telomeric joint molecule intermediates. We speculate that ablation of the Fanconi Anemia pathway would lead to inadequate aberrant structural barrier resolution at excessively long telomeres, thereby causing replicative burden on the cell." @default.
• W2328960066 created "2016-06-24" @default.
• W2328960066 creator A5030549134 @default.
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• W2328960066 date "2016-07-01" @default.
• W2328960066 modified "2023-10-11" @default.
• W2328960066 title "Fanconi anemia proteins in telomere maintenance" @default.
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• W2328960066 doi "https://doi.org/10.1016/j.dnarep.2016.02.007" @default.
• W2328960066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4917397" @default.
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