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• W2328994410 startingPage "9659" @default.
• W2328994410 abstract "The total synthesis of the structure assigned to the natural product phaeosphaeride A 1a was accomplished. The key steps involve the addition of vinyllithium reagent 7 to the acetonide-protected aldehyde 8 to access the carbon backbone of 1a, the introduction of the methoxylamino group followed by intramolecular hetero-Michael cyclization, and methanol elimination to form the dihydropyran ring. In this study, both enantiomers of 1a were synthesized and tested for biological activity. Preliminary results showed that (6R,7R,8R)-1a and (6S,7S,8S)-1a inhibit STAT3-dependent transcriptional activity in a dose-dependent manner and exhibit antiproliferative properties in breast (MDA-MB-231) and pancreatic (PANC-1) cancer cells." @default.
• W2328994410 created "2016-06-24" @default.
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• W2328994410 date "2012-10-18" @default.
• W2328994410 modified "2023-09-23" @default.
• W2328994410 title "Total Synthesis and Biological Activity of the Proposed Structure of Phaeosphaeride A" @default.
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• W2328994410 doi "https://doi.org/10.1021/jo301662e" @default.
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