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• W2328998047 abstract "The effect ofPG on patients with fulminant and subfulminant viral hepatitis (FHF) was studied. 17 patients presented with FHF secondary to hepatitis A (n = 3), hepatitis B (n = 6), and non-A, non-B (NANB) hepatitis (n = 8). 14 of the 17 patients had stage III or IV hepatic encephalopathy (HE). At presentation the mean aspartate transaminase (AST) was 1,844±1,246 U/liter, bilirubin 232±135 Mmol/liter, prothrombin time (PT) 34±18, partial thromboplastin time (PFT) 73±26 s, and coagulation Factors V and VII 8±4 and 9±5%, respectively. Intravenous PGE, was initiated 24-48 h later after a rise in AST (2,195±1,810), bilirubin (341±148), PT (36±15), and PIT (75±18). 12 of 17 responded rapidly with a decrease in AST from 1,540±833 to 188±324 U/liter. Improvement in hepatic synthetic function was indicated by a decrease in PT from 27±7 to 12±1 s and PTI from 61±10 to 31±2 s, and an increase in Factor V from 9±4 to 69±18% and Factor VII from 11±5 to 71±20%. Five responders with NANB hepatitis relapsed upon discontinuation of therapy, with recurrence ofHE and increases in AST and PT, and improvement was observed upon retreatment. After 4 wk ofintravenous therapy oral PGE2 was substituted. Two patients with NANB hepatitis recovered completely and remained in remission 6 and 12 mo after cessation of therapy. Two additional patients continued in remission after 2 and 6 mo of PGE2. No relapses were seen in the patients with hepatitis A virus and hepatitis B virus infection. Liver biopsies in all 12 surviving patients returned to normal. In the five nonresponders an improvement in hepatic function was indicated by a fall in AST (3,767±2,611 to 2,142±2,040 U/liter), PT (52±25 to 33±18 s), and PIT (103±29 to 77±44 s), but all deteriorated and died of cerebral edema (n = 3) or underwent liver transplantation (n = 2). These results suggest efficacy of PGE for FHF, and further investigation is warranted." @default.
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• W2328998047 date "1989-01-01" @default.
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• W2328998047 title "Biochemical and Clinical Response of Fulminant Viral Hepatitis to Administration of Prostaglandin E" @default.
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