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- W2329042783 startingPage "183" @default.
- W2329042783 abstract "Idiotype network systems are supposed to play important roles in regulation of the immune response. We applied anti-idiotypic(Id)monoclonal antibodies (MoAbs) to tumor associated antigen system to analyze idiotype networks and the internal image of antigen. Anti-Id MoAbs were developed to anti-CEA MoAb MA208 which reacted with peptide of CEA. One of the and-Id MoAbs, M7-625 could induce anti-anti-Id antibodies which reacted with antigen-CEA, suggesting that MoAb M7-625 serologically had the internal image of antigen. In order to confirm this point, the cloning experiment of M7-625 variable region was done. It showed that amino acid sequences of coplementary determining region (CDR) 2 and 3 of MoAb M7-625 heavy chain had the homology to those of CEA domain III. Furthermore, internal image-bearing anti-Id MoAb in ganglioside GM3 antigen system showed the vaccine effect against syngeneic B16 melanoma in C57/BL black mouse. These results suggest that internal image-bearing and-Id MoAbs are useful tools for cancer therapy." @default.
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- W2329042783 date "1991-01-01" @default.
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- W2329042783 title "Internal image-bearing anti-idiotypic antibody and the vaccine effect." @default.
- W2329042783 doi "https://doi.org/10.2745/dds.6.183" @default.
- W2329042783 hasPublicationYear "1991" @default.
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