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• W2329048052 startingPage "55" @default.
• W2329048052 abstract "Mesoporous silica nanoparticles (MSNs) exhibit significant advantages for efficient drug/gene delivery but it is hard for simple MSNs to deliver the loaded drug to the target sites of disease. Considering that there are some well-known pH differences in the body, it is a useful strategy to modify the exterior surface of MSNs with stimuli-responsive gatekeepers to realize open-close transformation of their mesopores. In this work, multifunctional pH-sensitive MSNs were designed with mixed polymeric coatings, that is, poly(ethylene glycol) (PEG) as a dispersity-enhancer and poly(2-(pentamethyleneimino)ethyl methacrylate) (PPEMA) as an ultra-pH-sensitive gatekeeper. Enhanced dispersity, high drug loading capacity, long-circulation time, pH-triggered targeting, and better cellular uptake of the multifunctional MSNs make them potential candidates for pH-sensitive drug delivery such as tumor therapy." @default.
• W2329048052 created "2016-06-24" @default.
• W2329048052 creator A5001553975 @default.
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• W2329048052 date "2015-12-16" @default.
• W2329048052 modified "2023-10-16" @default.
• W2329048052 title "Intelligent Drug Delivery System Based on Mesoporous Silica Nanoparticles Coated with an Ultra-pH-Sensitive Gatekeeper and Poly(ethylene glycol)" @default.
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• W2329048052 doi "https://doi.org/10.1021/acsmacrolett.5b00765" @default.
• W2329048052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35668579" @default.
• W2329048052 hasPublicationYear "2015" @default.
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