Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329055079> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2329055079 endingPage "211" @default.
- W2329055079 startingPage "205" @default.
- W2329055079 abstract "RATIONALE AND OBJECTIVES Recent studies indicate that manganese dipyridoxyl diphosphate (MnDPDP) may function as a slow release agent for manganese ions (Mn++) and that MnDPDP is approximately 10 times less potent than manganese chloride (MnCl2) in depressing cardiac function. The authors examined the possibility that MnDPDP and MnCl2 may influence cardiac metabolism and enzyme release and lead to a tissue accumulation of Mn. METHODS Manganese DPDP, DPDP--, or MnCl2 (1000µM) was infused in isolated rat hearts, which were freeze-clamped at various time intervals during infusion (5 minutes) and recovery (14-minute washout). Enzyme (lactate dehydrogenase) release, tissue high energy phosphates, Mn contents, and physiologic indices were measured at various time intervals. RESULTS No significant differences were noted for: lactate dehydrogenase in the treated groups; tissue creatine phosphate (CrP) and adenosine triphosphate in MnDPDP, DPDP--, and control groups; and tissue Mn in DPDP-- and control groups. Manganese-chloride and MnDPDP-treated hearts accumulated and retained Mn in an 8:1 ratio. Manganese chloride depressed cardiac function more effectively than MnDPDP. CONCLUSIONS The study has shown that: heart tissue uptake and retention of Mn++ is rapid and effective; MnCl2 is approximately eight times more potent than MnDPDP in promoting these effects; and a rise in tissue Mn content to eight to nine times (MnDPDP) or 60 to 70 times (MnCl2) the normal level does not lead to acute side effects on cardiac energy metabolism, function, and enzyme release. The study indicates that MnDPDP may act like a slow release compound for Mn++ ions." @default.
- W2329055079 created "2016-06-24" @default.
- W2329055079 creator A5017535283 @default.
- W2329055079 creator A5023126745 @default.
- W2329055079 creator A5030355112 @default.
- W2329055079 creator A5053529047 @default.
- W2329055079 creator A5067539275 @default.
- W2329055079 date "1997-04-01" @default.
- W2329055079 modified "2023-09-30" @default.
- W2329055079 title "Effects of MnDPDP, DPDP--, and MnCl2 on Cardiac Energy Metabolism and Manganese Accumulation" @default.
- W2329055079 cites W1556599665 @default.
- W2329055079 cites W1984177559 @default.
- W2329055079 cites W1987260003 @default.
- W2329055079 cites W1989419613 @default.
- W2329055079 cites W1991440090 @default.
- W2329055079 cites W1994231309 @default.
- W2329055079 cites W1994939649 @default.
- W2329055079 cites W1999329850 @default.
- W2329055079 cites W2014014915 @default.
- W2329055079 cites W2022708486 @default.
- W2329055079 cites W2032860837 @default.
- W2329055079 cites W2043155301 @default.
- W2329055079 cites W2043281920 @default.
- W2329055079 cites W2067963874 @default.
- W2329055079 cites W2068232246 @default.
- W2329055079 cites W2068526644 @default.
- W2329055079 cites W2090708021 @default.
- W2329055079 cites W2326757843 @default.
- W2329055079 cites W2335088247 @default.
- W2329055079 cites W2432195370 @default.
- W2329055079 cites W4298228374 @default.
- W2329055079 doi "https://doi.org/10.1097/00004424-199704000-00003" @default.
- W2329055079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9101355" @default.
- W2329055079 hasPublicationYear "1997" @default.
- W2329055079 type Work @default.
- W2329055079 sameAs 2329055079 @default.
- W2329055079 citedByCount "23" @default.
- W2329055079 countsByYear W23290550792015 @default.
- W2329055079 crossrefType "journal-article" @default.
- W2329055079 hasAuthorship W2329055079A5017535283 @default.
- W2329055079 hasAuthorship W2329055079A5023126745 @default.
- W2329055079 hasAuthorship W2329055079A5030355112 @default.
- W2329055079 hasAuthorship W2329055079A5053529047 @default.
- W2329055079 hasAuthorship W2329055079A5067539275 @default.
- W2329055079 hasConcept C111566952 @default.
- W2329055079 hasConcept C126322002 @default.
- W2329055079 hasConcept C178790620 @default.
- W2329055079 hasConcept C181199279 @default.
- W2329055079 hasConcept C185592680 @default.
- W2329055079 hasConcept C2777132085 @default.
- W2329055079 hasConcept C2777318727 @default.
- W2329055079 hasConcept C2778198053 @default.
- W2329055079 hasConcept C2778695967 @default.
- W2329055079 hasConcept C2779564974 @default.
- W2329055079 hasConcept C2779896295 @default.
- W2329055079 hasConcept C528890316 @default.
- W2329055079 hasConcept C55493867 @default.
- W2329055079 hasConcept C62231903 @default.
- W2329055079 hasConcept C71924100 @default.
- W2329055079 hasConceptScore W2329055079C111566952 @default.
- W2329055079 hasConceptScore W2329055079C126322002 @default.
- W2329055079 hasConceptScore W2329055079C178790620 @default.
- W2329055079 hasConceptScore W2329055079C181199279 @default.
- W2329055079 hasConceptScore W2329055079C185592680 @default.
- W2329055079 hasConceptScore W2329055079C2777132085 @default.
- W2329055079 hasConceptScore W2329055079C2777318727 @default.
- W2329055079 hasConceptScore W2329055079C2778198053 @default.
- W2329055079 hasConceptScore W2329055079C2778695967 @default.
- W2329055079 hasConceptScore W2329055079C2779564974 @default.
- W2329055079 hasConceptScore W2329055079C2779896295 @default.
- W2329055079 hasConceptScore W2329055079C528890316 @default.
- W2329055079 hasConceptScore W2329055079C55493867 @default.
- W2329055079 hasConceptScore W2329055079C62231903 @default.
- W2329055079 hasConceptScore W2329055079C71924100 @default.
- W2329055079 hasIssue "4" @default.
- W2329055079 hasLocation W23290550791 @default.
- W2329055079 hasLocation W23290550792 @default.
- W2329055079 hasOpenAccess W2329055079 @default.
- W2329055079 hasPrimaryLocation W23290550791 @default.
- W2329055079 hasRelatedWork W1581350964 @default.
- W2329055079 hasRelatedWork W1964034596 @default.
- W2329055079 hasRelatedWork W1985232408 @default.
- W2329055079 hasRelatedWork W2013916032 @default.
- W2329055079 hasRelatedWork W2036333506 @default.
- W2329055079 hasRelatedWork W2037678717 @default.
- W2329055079 hasRelatedWork W2067158676 @default.
- W2329055079 hasRelatedWork W2987454628 @default.
- W2329055079 hasRelatedWork W65461976 @default.
- W2329055079 hasRelatedWork W966738943 @default.
- W2329055079 hasVolume "32" @default.
- W2329055079 isParatext "false" @default.
- W2329055079 isRetracted "false" @default.
- W2329055079 magId "2329055079" @default.
- W2329055079 workType "article" @default.