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- W2329062174 endingPage "215" @default.
- W2329062174 startingPage "201" @default.
- W2329062174 abstract "Colorectal cancer (CRC) is one of the most frequent causes of cancer death worldwide and is associated with adoption of a diet high in animal protein and saturated fat. Saturated fat induces increased bile secretion into the intestine. Increased bile secretion selects for populations of gut microbes capable of altering the bile acid pool, generating tumor-promoting secondary bile acids such as deoxycholic acid and lithocholic acid. Epidemiological evidence suggests CRC is associated with increased levels of DCA in serum, bile, and stool. Mechanisms by which secondary bile acids promote CRC are explored. Furthermore, in humans bile acid conjugation can vary by diet. Vegetarian diets favor glycine conjugation while diets high in animal protein favor taurine conjugation. Metabolism of taurine conjugated bile acids by gut microbes generates hydrogen sulfide, a genotoxic compound. Thus, taurocholic acid has the potential to stimulate intestinal bacteria capable of converting taurine and cholic acid to hydrogen sulfide and deoxycholic acid, a genotoxin and tumor-promoter, respectively." @default.
- W2329062174 created "2016-06-24" @default.
- W2329062174 creator A5014700891 @default.
- W2329062174 creator A5023983153 @default.
- W2329062174 creator A5026366028 @default.
- W2329062174 date "2016-03-22" @default.
- W2329062174 modified "2023-10-14" @default.
- W2329062174 title "Taurocholic acid metabolism by gut microbes and colon cancer" @default.
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